Version 5.4
Homo sapiens Gene: CCR2
Summary
InnateDB Gene IDBG-30182.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCR2
Gene Name chemokine (C-C motif) receptor 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000121807
Encoded Proteins
IDBP-30184
chemokine (C-C motif) receptor 2
IDBP-227155
chemokine (C-C motif) receptor 2
IDBP-374487
chemokine (C-C motif) receptor 2
IDBP-374489
chemokine (C-C motif) receptor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene. [provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:46353734-46360928
Strand Forward strand
Band p21.31
Transcripts
ENST00000292301 ENSP00000292301
ENST00000400888 ENSP00000383681
ENST00000445132 ENSP00000399285
ENST00000421659 ENSP00000396736
ENST00000465202
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated
Total 22 [view]
Protein-Protein 20 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004950 chemokine receptor activity
GO:0016493 C-C chemokine receptor activity
GO:0031727 CCR2 chemokine receptor binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0001974 blood vessel remodeling
GO:0002407 dendritic cell chemotaxis
GO:0002827 positive regulation of T-helper 1 type immune response
GO:0002829 negative regulation of type 2 immune response
GO:0006874 cellular calcium ion homeostasis
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0006968 cellular defense response
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007194 negative regulation of adenylate cyclase activity
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007259 JAK-STAT cascade
GO:0009611 response to wounding
GO:0010574 regulation of vascular endothelial growth factor production
GO:0010820 positive regulation of T cell chemotaxis
GO:0016032 viral process
GO:0016525 negative regulation of angiogenesis
GO:0019221 cytokine-mediated signaling pathway
GO:0019725 cellular homeostasis
GO:0032729 positive regulation of interferon-gamma production
GO:0032743 positive regulation of interleukin-2 production
GO:0035705 T-helper 17 cell chemotaxis
GO:0042535 positive regulation of tumor necrosis factor biosynthetic process
GO:0043310 negative regulation of eosinophil degranulation
GO:0045087 innate immune response
GO:0046641 positive regulation of alpha-beta T cell proliferation
GO:0050729 positive regulation of inflammatory response
GO:0050870 positive regulation of T cell activation
GO:0070098 chemokine-mediated signaling pathway
GO:0090026 positive regulation of monocyte chemotaxis
GO:0090265 positive regulation of immune complex clearance by monocytes and macrophages
GO:2000439 positive regulation of monocyte extravasation
GO:2000451 positive regulation of CD8-positive, alpha-beta T cell extravasation
GO:2000464 positive regulation of astrocyte chemotaxis
GO:2000473 positive regulation of hematopoietic stem cell migration
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
GO:0030425 dendrite
GO:0043025 neuronal cell body
GO:0043204 perikaryon
GO:0048471 perinuclear region of cytoplasm
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_115897
Beta defensins pathway
REACT_115846
Defensins pathway
REACT_19231
G alpha (i) signalling events pathway
REACT_15344
Chemokine receptors bind chemokines pathway
REACT_14819
Peptide ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_6802
Innate Immune System pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_6900
Immune System pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04062
Chemokine signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt P41597
TrEMBL B4XH69 E9PH76 L7REX9
UniProt Splice Variant
Entrez Gene 729230
UniGene Hs.511794 Hs.705362
RefSeq NM_001123041 NM_001123396
HUGO HGNC:1603
OMIM 601267
CCDS CCDS43078 CCDS46813
HPRD
IMGT
EMBL AC098613 AC138069 AF545480 AK292685 AK292920 BC074751 BC095540 BC126452 BC136396 CH471055 D29984 EU037783 KC248071 KC248072 KC248073 KC248074 KC248075 KC248076 KC248078 KC248079 U03882 U03905 U80924 U95626
GenPept AAA19119 AAA19120 AAB57791 AAB57792 AAC51636 AAC51637 AAH74751 AAH95540 AAI26453 AAI36397 AAN16400 ABW17217 AGC02843 AGC02844 AGC02845 AGC02846 AGC02847 AGC02848 AGC02850 AGC02851 BAA06253 BAF85374 BAF85609 EAW64760
RNA Seq Atlas 729230

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca