Version 5.4
Homo sapiens Gene: CCR5
Summary
InnateDB Gene IDBG-30229.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCR5
Gene Name chemokine (C-C motif) receptor 5 (gene/pseudogene)
Synonyms CC-CKR-5; CCCKR5; CCR-5; CD195; CKR-5; CKR5; CMKBR5; IDDM22
Species Homo sapiens
Ensembl Gene ENSG00000160791
Encoded Proteins
IDBP-30231
chemokine (C-C motif) receptor 5
IDBP-374504
chemokine (C-C motif) receptor 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:46370854-46376206
Strand Forward strand
Band p21.31
Transcripts
ENST00000292303 ENSP00000292303
ENST00000445772 ENSP00000404881
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 42 [view]
Protein-Protein 39 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0004930 G-protein coupled receptor activity
GO:0004950 chemokine receptor activity
GO:0005515 protein binding
GO:0015026 coreceptor activity
GO:0016493 C-C chemokine receptor activity
GO:0019957 C-C chemokine binding
GO:0071791 chemokine (C-C motif) ligand 5 binding
Biological Process
GO:0000165 MAPK cascade
GO:0002407 dendritic cell chemotaxis
GO:0006816 calcium ion transport
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0006968 cellular defense response
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007267 cell-cell signaling
GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0016032 viral process
GO:0019722 calcium-mediated signaling
GO:0023052 signaling
GO:0030260 entry into host cell
GO:0070098 chemokine-mediated signaling pathway
GO:0070723 response to cholesterol
GO:0071222 cellular response to lipopolysaccharide
Cellular Component
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000079227
View Gene Order
ENSBTAG00000008099
Not yet available
Pathways
NETPATH
REACTOME
REACT_19231
G alpha (i) signalling events pathway
REACT_15344
Chemokine receptors bind chemokines pathway
REACT_14819
Peptide ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_6903
Binding and entry of HIV virion pathway
REACT_6266
Early Phase of HIV Life Cycle pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_6256
HIV Life Cycle pathway
REACT_6185
HIV Infection pathway
REACT_21340
GPCR ligand binding pathway
REACT_116125
Disease pathway
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04144
Endocytosis pathway
hsa04062
Chemokine signaling pathway pathway
hsa05145
Toxoplasmosis pathway
INOH
PID NCI
il12_2pathway
IL12-mediated signaling events
Cross-References
SwissProt P51681
TrEMBL A1A490 B8LFN8 B8LFP0 E7BJ57 J7HJP8 Q38L21 Q5EKN0 Q5KSY4 Q9P1T4 Q9UBT9
UniProt Splice Variant
Entrez Gene 1234
UniGene Hs.450802
RefSeq NM_000579 NM_001100168
HUGO HGNC:1606
OMIM 601373
CCDS CCDS2739
HPRD
IMGT
EMBL AB182984 AB182988 AB182990 AF011500 AF011501 AF011502 AF011503 AF011505 AF011506 AF011507 AF011508 AF011509 AF011510 AF011511 AF011512 AF011513 AF011514 AF011515 AF011516 AF011517 AF011518 AF011519 AF011520 AF011521 AF011522 AF011523 AF011524 AF011525 AF011526 AF011527 AF011528 AF011529 AF011530 AF011531 AF011532 AF011533 AF011534 AF011535 AF011536 AF011537 AF031237 AF052539 AF056020 AF161909 AF161910 AF161911 AF161912 AF161915 AK292132 AY221093 AY874119 AY947540 BC038398 CH471055 DQ217934 EF202087 EF202089 EF408698 EF408699 EF408700 GQ121035 GQ917109 JQ291182 JQ291183 JQ291184 JQ291185 JQ291186 JQ291187 JQ291188 JQ291190 JQ291191 JQ291192 JQ291193 JQ291194 JQ291195 JQ291196 JQ291197 JQ291198 JQ291199 JQ291200 JQ291201 JQ291202 JQ291203 JQ291204 JQ291205 JQ291206 JQ291207 JQ291208 JQ291209 JQ291210 JQ291211 JQ291212 JQ291213 JQ291214 JQ291215 JQ291216 JQ291217 JQ291218 JQ291219 JQ291220 JQ291221 JQ291222 JQ291223 JQ291224 JX141387 JX141394 KC248080 KC248081 KC248082 KC248083 KC248084 KC248085 KC248086 KC248087 KC248089 U54994 U57840 U83326 U95626 X91492
GenPept AAB17071 AAB57793 AAB65700 AAB65701 AAB65702 AAB65703 AAB65705 AAB65706 AAB65707 AAB65708 AAB65709 AAB65710 AAB65711 AAB65712 AAB65713 AAB65714 AAB65715 AAB65716 AAB65717 AAB65718 AAB65719 AAB65720 AAB65721 AAB65722 AAB65723 AAB65724 AAB65725 AAB65726 AAB65727 AAB65728 AAB65729 AAB65730 AAB65731 AAB65732 AAB65733 AAB65734 AAB65735 AAB65736 AAB65737 AAB94735 AAC50598 AAC51797 AAD18131 AAD47666 AAD47667 AAD47668 AAD47669 AAD47672 AAF65579 AAH38398 AAO65971 AAW82037 AAY23359 ABB01004 ABQ95606 ABQ95607 ABQ95608 ABU55681 ABU55683 ACX50405 ADC94815 AEZ06624 AEZ06625 AEZ06626 AEZ06627 AEZ06628 AEZ06629 AEZ06630 AEZ06632 AEZ06633 AEZ06634 AEZ06635 AEZ06636 AEZ06637 AEZ06638 AEZ06639 AEZ06640 AEZ06641 AEZ06642 AEZ06643 AEZ06644 AEZ06645 AEZ06646 AEZ06647 AEZ06648 AEZ06649 AEZ06650 AEZ06651 AEZ06652 AEZ06653 AEZ06654 AEZ06655 AEZ06656 AEZ06657 AEZ06658 AEZ06659 AEZ06660 AEZ06661 AEZ06662 AEZ06663 AEZ06664 AEZ06665 AEZ06666 AFP99926 AFP99933 AGC13086 AGC13087 AGC13088 AGC13089 AGC13090 AGC13091 AGC13092 AGC13093 AGC13095 BAD83805 BAD83807 BAD83808 BAF84821 CAA62796 EAW64763
RNA Seq Atlas 1234

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca