Version 5.4
Homo sapiens Gene: GRID2
Summary
InnateDB Gene IDBG-30249.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GRID2
Gene Name glutamate receptor, ionotropic, delta 2
Synonyms GluD2
Species Homo sapiens
Ensembl Gene ENSG00000152208
Encoded Proteins
IDBP-30251
glutamate receptor, ionotropic, delta 2
IDBP-479148
glutamate receptor, ionotropic, delta 2
IDBP-478266
glutamate receptor, ionotropic, delta 2
IDBP-482411
glutamate receptor, ionotropic, delta 2
IDBP-483652
glutamate receptor, ionotropic, delta 2
IDBP-807113
glutamate receptor, ionotropic, delta 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Human glutamate receptor delta-2 (GRID2) is a relatively new member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. GRID2 is a predicted 1,007 amino acid protein that shares 97% identity with the mouse homolog which is expressed selectively in cerebellar Purkinje cells. A point mutation in mouse GRID2, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This strongly suggests a role for GRID2 in neuronal apoptotic death. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named \'lurcher\', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause cerebellar ataxia in humans. [provided by RefSeq, Apr 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:92304399-93774556
Strand Forward strand
Band q22.1
Transcripts
ENST00000282020 ENSP00000282020
ENST00000505687
ENST00000510992 ENSP00000421257
ENST00000515744
ENST00000502699 ENSP00000422845
ENST00000512631 ENSP00000423331
ENST00000513976 ENSP00000425794
ENST00000611049 ENSP00000483084
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004970 ionotropic glutamate receptor activity
GO:0005215 transporter activity
GO:0005234 extracellular-glutamate-gated ion channel activity
GO:0005515 protein binding
GO:0008066 glutamate receptor activity
GO:0030165 PDZ domain binding
GO:0097110 scaffold protein binding
Biological Process
GO:0006810 transport
GO:0007157 heterophilic cell-cell adhesion
GO:0007215 glutamate receptor signaling pathway
GO:0010975 regulation of neuron projection development
GO:0021707 cerebellar granule cell differentiation
GO:0034220 ion transmembrane transport
GO:0034613 cellular protein localization
GO:0035235 ionotropic glutamate receptor signaling pathway
GO:0035249 synaptic transmission, glutamatergic
GO:0043523 regulation of neuron apoptotic process
GO:0060079 regulation of excitatory postsynaptic membrane potential
GO:0060134 prepulse inhibition
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0008328 ionotropic glutamate receptor complex
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0030425 dendrite
GO:0043197 dendritic spine
GO:0045202 synapse
GO:0045211 postsynaptic membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000071424
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
hsa04730
Long-term depression pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.162727 Hs.480281
RefSeq NM_001286838 NM_001510
HUGO
OMIM
CCDS CCDS3637 CCDS68758
HPRD 06781
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca