Homo sapiens Gene: ADRBK2
Summary
InnateDB Gene IDBG-3038.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADRBK2
Gene Name adrenergic, beta, receptor kinase 2
Synonyms BARK2; GRK3;
Species Homo sapiens
Ensembl Gene ENSG00000100077
Encoded Proteins
adrenergic, beta, receptor kinase 2
adrenergic, beta, receptor kinase 2
adrenergic, beta, receptor kinase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function. [provided by RefSeq, Jul 2008]
The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85%% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95%% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:25564849-25729294
Strand Forward strand
Band q12.1
Transcripts
ENST00000324198 ENSP00000317578
ENST00000455558 ENSP00000393688
ENST00000619906 ENSP00000478925
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004703 G-protein coupled receptor kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0047696 beta-adrenergic receptor kinase activity
Biological Process
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0031623 receptor internalization
GO:0038032 termination of G-protein coupled receptor signaling pathway
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
IL4 pathway
REACTOME
KEGG
Chemokine signaling pathway pathway
Endocytosis pathway
Olfactory transduction pathway
INOH
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
PID BIOCARTA
PID NCI
PAR1-mediated thrombin signaling events
Cross-References
SwissProt
TrEMBL H7C099
UniProt Splice Variant
Entrez Gene 157
UniGene Hs.657494
RefSeq NM_005160 XM_006724158
HUGO HGNC:290
OMIM 109636
CCDS CCDS13832
HPRD 00183
IMGT
EMBL AL022329
GenPept
RNA Seq Atlas 157