InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: LCP1

Summary

InnateDB Gene

IDBG-30382.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LCP1

Gene Name

lymphocyte cytosolic protein 1 (L-plastin)

Synonyms

CP64; HEL-S-37; L-PLASTIN; LC64P; LPL; PLS2

Species

Homo sapiens

Ensembl Gene

ENSG00000136167

Encoded Proteins

IDBP-30384

lymphocyte cytosolic protein 1 (L-plastin)

IDBP-232734

lymphocyte cytosolic protein 1 (L-plastin)

IDBP-367314

lymphocyte cytosolic protein 1 (L-plastin)

IDBP-367318

lymphocyte cytosolic protein 1 (L-plastin)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:46125920-46211871

Strand

Reverse strand

Band

q14.13

Transcripts

ENST00000323076	ENSP00000315757
ENST00000398576	ENSP00000381581
ENST00000416500	ENSP00000408052
ENST00000442275	ENSP00000402157
ENST00000469227
ENST00000494531
ENST00000460190

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0051015	actin filament binding

Biological Process

GO:0002286	T cell activation involved in immune response
GO:0010737	protein kinase A signaling
GO:0016477	cell migration
GO:0031100	organ regeneration
GO:0033157	regulation of intracellular protein transport
GO:0051017	actin filament bundle assembly

Cellular Component

GO:0001725	stress fiber
GO:0001726	ruffle
GO:0001891	phagocytic cup
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005884	actin filament
GO:0005886	plasma membrane
GO:0005925	focal adhesion
GO:0015629	actin cytoskeleton
GO:0030175	filopodium
GO:0032432	actin filament bundle
GO:0032587	ruffle membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000021998

View Gene Order

ENSBTAG00000007079

Not yet available

Pathways

NETPATH

NetPath_24

TSLP pathway

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

P13796

TrEMBL

A0A024RDT4 Q5TBN3 Q5TBN5

UniProt Splice Variant

Entrez Gene

3936

UniGene

Hs.381099

RefSeq

NM_002298 XM_005266374

HUGO

HGNC:6528

OMIM

153430

CCDS

CCDS9403

HPRD

01082

IMGT

EMBL

AH002870 AK312393 AL137141 BC007673 BC010271 CH471075 J02923 M22300 M34426

GenPept

AAA36184 AAA59529 AAA63236 AAB02845 AAH07673 AAH10271 BAG35310 CAI12168 EAX08757 EAX08758

RNA Seq Atlas

3936