Version 5.4
Homo sapiens Gene: TAPBP
Summary
InnateDB Gene IDBG-304230.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TAPBP
Gene Name TAP binding protein (tapasin)
Synonyms NGS17; TAPA; TPN; TPSN
Species Homo sapiens
Ensembl Gene ENSG00000231925
Encoded Proteins
IDBP-375609
TAP binding protein (tapasin)
IDBP-375615
TAP binding protein (tapasin)
IDBP-375617
TAP binding protein (tapasin)
IDBP-474502
TAP binding protein (tapasin)
IDBP-483817
TAP binding protein (tapasin)
IDBP-482391
TAP binding protein (tapasin)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:33299694-33314387
Strand Reverse strand
Band p21.32
Transcripts
ENST00000434618 ENSP00000395701
ENST00000426633 ENSP00000404833
ENST00000456592 ENSP00000387803
ENST00000437116
ENST00000475304 ENSP00000417949
ENST00000489157 ENSP00000419659
ENST00000480730
ENST00000467025 ENSP00000417523
ENST00000476333
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 13 [view]
Protein-DNA 3 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0015433 peptide antigen-transporting ATPase activity
GO:0042288 MHC class I protein binding
GO:0042605 peptide antigen binding
GO:0046978 TAP1 binding
GO:0046979 TAP2 binding
GO:0051082 unfolded protein binding
Biological Process
GO:0002397 MHC class I protein complex assembly
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0006461 protein complex assembly
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER
GO:0006952 defense response
GO:0006955 immune response
GO:0015833 peptide transport
GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I
GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042886 amide transport
GO:0050823 peptide antigen stabilization
Cellular Component
GO:0000139 Golgi membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0042824 MHC class I peptide loading complex
GO:0042825 TAP complex
GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024308
View Gene Order
ENSBTAG00000016828
Not yet available
Pathways
NETPATH
REACTOME
REACT_75795
Antigen Presentation: Folding, assembly and peptide loading of class I MHC pathway
REACT_111178
ER-Phagosome pathway pathway
REACT_111119
Antigen processing-Cross presentation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
hsa04612
Antigen processing and presentation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.370937 Hs.722317
RefSeq NM_003190 NM_172208 NM_172209
HUGO
OMIM
CCDS CCDS34426 CCDS34427 CCDS34428
HPRD 09061
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca