InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: LTF

Summary

InnateDB Gene

IDBG-30438.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LTF

Gene Name

lactotransferrin

Synonyms

GIG12; HEL110; HLF2; LF

Species

Homo sapiens

Ensembl Gene

ENSG00000012223

Encoded Proteins

IDBP-30440

lactotransferrin

IDBP-374584

lactotransferrin

IDBP-374587

lactotransferrin

IDBP-374593

lactotransferrin

IDBP-374601

lactotransferrin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of the transferrin family of genes and its protein product is found in the secondary granules of neutrophils. The protein is a major iron-binding protein in milk and body secretions with an antimicrobial activity, making it an important component of the non-specific immune system. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
This gene is a member of the transferrin family of genes and its protein product is found in the secondary granules of neutrophils. The protein is a major iron-binding protein in milk and body secretions with an antimicrobial activity, making it an important component of the non-specific immune system. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. Antimicrobial, antiviral, antifungal and antiparasitic activity has been found for this protein and its peptides. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:46435645-46485234

Strand

Reverse strand

Band

p21.31

Transcripts

ENST00000231751	ENSP00000231751
ENST00000417439	ENSP00000405546
ENST00000443496	ENSP00000397427
ENST00000426532	ENSP00000405719
ENST00000431944	ENSP00000395234
ENST00000493056
ENST00000478874
ENST00000462667
ENST00000498301

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	21 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0004252	serine-type endopeptidase activity
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0008199	ferric iron binding
GO:0008201	heparin binding
GO:0008233	peptidase activity
GO:0043539	protein serine/threonine kinase activator activity

Biological Process

GO:0001503	ossification
GO:0001817	regulation of cytokine production
GO:0001895	retina homeostasis
GO:0002227	innate immune response in mucosa
GO:0006351	transcription, DNA-templated
GO:0006508	proteolysis
GO:0006826	iron ion transport
GO:0006879	cellular iron ion homeostasis
GO:0006959	humoral immune response
GO:0019731	antibacterial humoral response
GO:0019732	antifungal humoral response
GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway
GO:0032680	regulation of tumor necrosis factor production
GO:0033214	iron assimilation by chelation and transport
GO:0033690	positive regulation of osteoblast proliferation
GO:0034145	positive regulation of toll-like receptor 4 signaling pathway
GO:0043066	negative regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045669	positive regulation of osteoblast differentiation
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051701	interaction with host
GO:0052572	response to host immune response
GO:0060349	bone morphogenesis
GO:0071902	positive regulation of protein serine/threonine kinase activity
GO:0090382	phagosome maturation
GO:1900159	positive regulation of bone mineralization involved in bone maturation
GO:1900229	negative regulation of single-species biofilm formation in or on host organism
GO:1902732	positive regulation of chondrocyte proliferation
GO:2000308	negative regulation of tumor necrosis factor (ligand) superfamily member 11 production
GO:2001205	negative regulation of osteoclast development

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0030141	secretory granule
GO:0042581	specific granule
GO:0070062	extracellular vesicular exosome
GO:0097013	phagocytic vesicle lumen

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000032496

View Gene Order

ENSBTAG00000001292

Not yet available

Pathways

NETPATH

REACTOME

REACT_75925

Amyloids pathway

REACT_121256

Phagosomal maturation (early endosomal stage) pathway

REACT_121118

Mtb iron assimilation by chelation pathway

REACT_121042

Response of Mtb to phagocytosis pathway

REACT_121237

Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway

REACT_116125

Disease pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.529517 Hs.610567 Hs.739670

RefSeq

NM_001199149 NM_002343

HUGO

OMIM

CCDS

CCDS33747 CCDS56251

HPRD

01028

IMGT

EMBL

GenPept

RNA Seq Atlas