InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DDX23

Summary

InnateDB Gene

IDBG-30453.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DDX23

Gene Name

DEAD (Asp-Glu-Ala-Asp) box polypeptide 23

Synonyms

prp28; PRPF28; SNRNP100; U5-100K; U5-100KD

Species

Homo sapiens

Ensembl Gene

ENSG00000174243

Encoded Proteins

IDBP-30455

DEAD (Asp-Glu-Ala-Asp) box polypeptide 23

IDBP-593037

DEAD (Asp-Glu-Ala-Asp) box polypeptide 23

IDBP-593835

DEAD (Asp-Glu-Ala-Asp) box polypeptide 23

IDBP-600189

DEAD (Asp-Glu-Ala-Asp) box polypeptide 23

IDBP-599681

DEAD (Asp-Glu-Ala-Asp) box polypeptide 23

IDBP-592039

DEAD (Asp-Glu-Ala-Asp) box polypeptide 23

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a component of the U5 snRNP complex; it may facilitate conformational changes in the spliceosome during nuclear pre-mRNA splicing. An alternatively spliced transcript variant has been found for this gene, but its biological validity has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:48829764-48852842

Strand

Reverse strand

Band

q13.12

Transcripts

ENST00000308025	ENSP00000310723
ENST00000550834	ENSP00000449657
ENST00000551331
ENST00000549795
ENST00000547842
ENST00000552802	ENSP00000448542
ENST00000547290
ENST00000553065
ENST00000547135	ENSP00000446770
ENST00000547165
ENST00000552069
ENST00000551189
ENST00000553182
ENST00000551098
ENST00000552512	ENSP00000449639
ENST00000552369
ENST00000551468	ENSP00000446948
ENST00000552555

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.

Experimentally validated
Total	39 [view]
Protein-Protein	38 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0004004	ATP-dependent RNA helicase activity
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000354	cis assembly of pre-catalytic spliceosome
GO:0000375	RNA splicing, via transesterification reactions
GO:0000398	mRNA splicing, via spliceosome
GO:0006200	ATP catabolic process
GO:0008152	metabolic process
GO:0008380	RNA splicing
GO:0010467	gene expression

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005682	U5 snRNP
GO:0005739	mitochondrion
GO:0005886	plasma membrane
GO:0070062	extracellular vesicular exosome
GO:0071013	catalytic step 2 spliceosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000003360

View Gene Order

ENSBTAG00000021810

Not yet available

Pathways

NETPATH

REACTOME

REACT_467

mRNA Splicing - Major Pathway pathway

REACT_1753

mRNA Splicing - Minor Pathway pathway

REACT_125

Processing of Capped Intron-Containing Pre-mRNA pathway

REACT_1735

mRNA Splicing pathway

REACT_71

Gene Expression pathway

KEGG

hsa03040

Spliceosome pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

H0YIL9

UniProt Splice Variant

Entrez Gene

9416

UniGene

Hs.130098

RefSeq

NM_004818 XM_006719699

HUGO

HGNC:17347

OMIM

612172

CCDS

CCDS8770

HPRD

09908

IMGT

EMBL

AC117498

GenPept

RNA Seq Atlas

9416