InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ARF3

Summary

InnateDB Gene

IDBG-30640.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARF3

Gene Name

ADP-ribosylation factor 3

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000134287

Encoded Proteins

IDBP-30642

ADP-ribosylation factor 3

IDBP-587318

ADP-ribosylation factor 3

IDBP-374041

ADP-ribosylation factor 3

IDBP-601177

ADP-ribosylation factor 3

IDBP-598872

ADP-ribosylation factor 3

IDBP-591149

ADP-ribosylation factor 3

IDBP-592198

ADP-ribosylation factor 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

ADP-ribosylation factor 3 (ARF3) is a member of the human ARF gene family. These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 6 ARF proteins and 11 ARF-like proteins and constitute 1 family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2,and ARF3), class II (ARF4 and ARF5) and class III (ARF6) and members of each class share a common gene organization. The ARF3 gene contains five exons and four introns. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:48935723-48957551

Strand

Reverse strand

Band

q13.12

Transcripts

ENST00000256682	ENSP00000256682
ENST00000398092	ENSP00000438507
ENST00000447318	ENSP00000395370
ENST00000485410
ENST00000472621
ENST00000541959	ENSP00000438510
ENST00000541236	ENSP00000438063
ENST00000539611	ENSP00000437374
ENST00000545855	ENSP00000446353
ENST00000541967
ENST00000536283

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0004871	signal transducer activity
GO:0005525	GTP binding
GO:0019001	guanyl nucleotide binding
GO:0031683	G-protein beta/gamma-subunit complex binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006644	phospholipid metabolic process
GO:0006661	phosphatidylinositol biosynthetic process
GO:0006886	intracellular protein transport
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport
GO:0044281	small molecule metabolic process

Cellular Component

GO:0000139	Golgi membrane
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome

Orthologs

No orthologs found for this gene

Pathways

NETPATH

REACTOME

REACT_120836

Synthesis of PIPs at the Golgi membrane pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_121175

PI Metabolism pathway

REACT_120870

Phospholipid metabolism pathway

REACT_111217

Metabolism pathway

KEGG

hsa04144

Endocytosis pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.119177 Hs.634075

RefSeq

NM_001659 XM_006719391

HUGO

OMIM

CCDS

CCDS8774

HPRD

00056

IMGT

EMBL

GenPept

RNA Seq Atlas