Version 5.4
Homo sapiens Gene: TTC3
Summary
InnateDB Gene IDBG-3083.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TTC3
Gene Name tetratricopeptide repeat domain 3
Synonyms DCRR1; RNF105; TPRDIII
Species Homo sapiens
Ensembl Gene ENSG00000182670
Encoded Proteins
IDBP-3085
tetratricopeptide repeat domain 3
IDBP-3087
tetratricopeptide repeat domain 3
IDBP-231514
tetratricopeptide repeat domain 3
IDBP-231516
tetratricopeptide repeat domain 3
IDBP-365381
tetratricopeptide repeat domain 3
IDBP-365383
tetratricopeptide repeat domain 3
IDBP-365385
tetratricopeptide repeat domain 3
IDBP-365440
tetratricopeptide repeat domain 3
IDBP-365441
tetratricopeptide repeat domain 3
IDBP-365445
tetratricopeptide repeat domain 3
IDBP-586339
tetratricopeptide repeat domain 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 21:37073226-37203112
Strand Forward strand
Band q22.13
Transcripts
ENST00000354749 ENSP00000346791
ENST00000355666 ENSP00000347889
ENST00000399017 ENSP00000381981
ENST00000399010 ENSP00000381974
ENST00000418766 ENSP00000403943
ENST00000438055 ENSP00000391891
ENST00000450533 ENSP00000408456
ENST00000414818 ENSP00000414658
ENST00000411496 ENSP00000387880
ENST00000428693 ENSP00000393681
ENST00000492275
ENST00000485402
ENST00000481605
ENST00000463216
ENST00000494243
ENST00000484047
ENST00000479930
ENST00000460328
ENST00000491952
ENST00000476784
ENST00000487711
ENST00000472398
ENST00000469939
ENST00000488522
ENST00000540756 ENSP00000442875
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0010771 negative regulation of cell morphogenesis involved in differentiation
GO:0045665 negative regulation of neuron differentiation
GO:0070936 protein K48-linked ubiquitination
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005773 vacuole
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040785
View Gene Order
ENSBTAG00000008167
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.368214 Hs.567832 Hs.602285 Hs.609880 Hs.618500
RefSeq NM_001001894 NM_003316 XM_005261047 XM_005261051
HUGO
OMIM
CCDS CCDS13651
HPRD 03773
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca