Version 5.4
Homo sapiens Gene: RGMA
Summary
InnateDB Gene IDBG-31194.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RGMA
Gene Name RGM domain family, member A
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000182175
Encoded Proteins
IDBP-31196
RGM domain family, member A
IDBP-380816
RGM domain family, member A
IDBP-592404
RGM domain family, member A
IDBP-584902
RGM domain family, member A
IDBP-590151
RGM domain family, member A
IDBP-587159
RGM domain family, member A
IDBP-747314
IDBP-603486
RGM domain family, member A
IDBP-585026
RGM domain family, member A
IDBP-587428
RGM domain family, member A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the repulsive guidance molecule family. The encoded protein is a glycosylphosphatidylinositol-anchored glycoprotein that functions as an axon guidance protein in the developing and adult central nervous system. This protein may also function as a tumor suppressor in some cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:93035273-93089204
Strand Reverse strand
Band q26.1
Transcripts
ENST00000329082 ENSP00000330005
ENST00000425933 ENSP00000404442
ENST00000542321 ENSP00000440025
ENST00000554387 ENSP00000451505
ENST00000557301 ENSP00000452126
ENST00000557420 ENSP00000452170
ENST00000556658 ENSP00000456290
ENST00000555584
ENST00000555598 ENSP00000451709
ENST00000557608
ENST00000556950 ENSP00000452350
ENST00000543599 ENSP00000442498
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0015026 coreceptor activity
Biological Process
GO:0001843 neural tube closure
GO:0007411 axon guidance
GO:0030509 BMP signaling pathway
GO:0030510 regulation of BMP signaling pathway
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0031225 anchored component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000070509
View Gene Order
ENSBTAG00000018603
Not yet available
Pathways
NETPATH
REACTOME
REACT_22237
Netrin-1 signaling pathway
REACT_111045
Developmental Biology pathway
REACT_18266
Axon guidance pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001166283 NM_001166286 NM_001166287 NM_001166288 NM_001166289 NM_020211
HUGO
OMIM
CCDS CCDS45357 CCDS53973 CCDS53974
HPRD 09560
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca