Homo sapiens Gene: ADH1B
Summary
InnateDB Gene IDBG-31258.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADH1B
Gene Name alcohol dehydrogenase 1B (class I), beta polypeptide
Synonyms ADH2; HEL-S-117;
Species Homo sapiens
Ensembl Gene ENSG00000196616
Encoded Proteins
alcohol dehydrogenase 1B (class I), beta polypeptide
alcohol dehydrogenase 1B (class I), beta polypeptide
alcohol dehydrogenase 1B (class I), beta polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This encoded protein, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This encoded protein, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:99304964-99321442
Strand Reverse strand
Band q23
Transcripts
ENST00000305046 ENSP00000306606
ENST00000394887 ENSP00000378351
ENST00000515694
ENST00000506651 ENSP00000425998
ENST00000504498
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 7 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004024 alcohol dehydrogenase activity, zinc-dependent
GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups
Biological Process
GO:0006069 ethanol oxidation
GO:0006805 xenobiotic metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Metabolism pathway
Biological oxidations pathway
Ethanol oxidation pathway
Phase 1 - Functionalization of compounds pathway
KEGG
Glycolysis / Gluconeogenesis pathway
Fatty acid degradation pathway
Tyrosine metabolism pathway
Retinol metabolism pathway
Metabolism of xenobiotics by cytochrome P450 pathway
Drug metabolism pathway
INOH
Tyrosine metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.4 Hs.613968
RefSeq NM_000668 NM_001286650 XM_006714079
HUGO
OMIM
CCDS CCDS34033 CCDS68761
HPRD 00065
IMGT
EMBL
GenPept
RNA Seq Atlas