Version 5.4
Homo sapiens Gene: NFIX
Summary
InnateDB Gene IDBG-31627.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NFIX
Gene Name nuclear factor I/X (CCAAT-binding transcription factor)
Synonyms MRSHSS; NF1A; SOTOS2
Species Homo sapiens
Ensembl Gene ENSG00000008441
Encoded Proteins
IDBP-31631
nuclear factor I/X (CCAAT-binding transcription factor)
IDBP-31635
nuclear factor I/X (CCAAT-binding transcription factor)
IDBP-234880
nuclear factor I/X (CCAAT-binding transcription factor)
IDBP-765843
IDBP-763065
IDBP-765352
IDBP-760328
IDBP-765004
IDBP-764742
IDBP-762864
IDBP-764449
IDBP-760930
IDBP-760166
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a transcription factor that binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3 in viral and cellular promoters. The encoded protein can also stimulate adenovirus replication in vitro. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2012]
The protein encoded by this gene is a transcription factor that binds the palindromic sequence 5\'-TTGGCNNNNNGCCAA-3 in viral and cellular promoters. The encoded protein can also stimulate adenovirus replication in vitro. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:12995608-13098796
Strand Forward strand
Band p13.13
Transcripts
ENST00000360105 ENSP00000353219
ENST00000358552 ENSP00000351354
ENST00000397661 ENSP00000380781
ENST00000590027 ENSP00000465616
ENST00000585382 ENSP00000466605
ENST00000592199 ENSP00000467512
ENST00000587760 ENSP00000466389
ENST00000588228 ENSP00000466735
ENST00000585575 ENSP00000468794
ENST00000586797 ENSP00000467536
ENST00000587260 ENSP00000467785
ENST00000591028 ENSP00000465094
ENST00000588680
ENST00000586873 ENSP00000468707
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 12 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006260 DNA replication
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0021549 cerebellum development
GO:0021680 cerebellar Purkinje cell layer development
GO:0021707 cerebellar granule cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048708 astrocyte differentiation
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000001911
View Gene Order
ENSBTAG00000018229
Not yet available
Pathways
NETPATH
REACTOME
REACT_22339
RNA Polymerase III Abortive And Retractive Initiation pathway
REACT_63
RNA Polymerase III Transcription Termination pathway
REACT_1371
RNA Polymerase III Transcription pathway
REACT_21352
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q14938
TrEMBL K7EKH0 K7ESG9
UniProt Splice Variant
Entrez Gene 4784
UniGene Hs.597451 Hs.619048 Hs.621701
RefSeq NM_002501 NM_001271043 NM_001271044 XM_006722760
HUGO HGNC:7788
OMIM 164005
CCDS CCDS45996 CCDS59359
HPRD 01234
IMGT
EMBL AC004660 AC007787 AC022152 AC138474 AK297261 BC117113 BC117115 BT019732 CH471106 L31881 U07811 U18759 U18761
GenPept AAA53422 AAA93126 AAB52369 AAB52371 AAC15752 AAD38240 AAD38241 AAI17114 AAI17116 AAV38537 BAG59737 EAW84340
RNA Seq Atlas 4784

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca