Homo sapiens Gene: NFIX
Summary
InnateDB Gene IDBG-31627.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NFIX
Gene Name nuclear factor I/X (CCAAT-binding transcription factor)
Synonyms MRSHSS; NF1A; SOTOS2;
Species Homo sapiens
Ensembl Gene ENSG00000008441
Encoded Proteins
nuclear factor I/X (CCAAT-binding transcription factor)
nuclear factor I/X (CCAAT-binding transcription factor)
nuclear factor I/X (CCAAT-binding transcription factor)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a transcription factor that binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3 in viral and cellular promoters. The encoded protein can also stimulate adenovirus replication in vitro. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2012]
The protein encoded by this gene is a transcription factor that binds the palindromic sequence 5\'-TTGGCNNNNNGCCAA-3 in viral and cellular promoters. The encoded protein can also stimulate adenovirus replication in vitro. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:12995608-13098796
Strand Forward strand
Band p13.13
Transcripts
ENST00000360105 ENSP00000353219
ENST00000358552 ENSP00000351354
ENST00000397661 ENSP00000380781
ENST00000590027 ENSP00000465616
ENST00000585382 ENSP00000466605
ENST00000592199 ENSP00000467512
ENST00000587760 ENSP00000466389
ENST00000588228 ENSP00000466735
ENST00000585575 ENSP00000468794
ENST00000586797 ENSP00000467536
ENST00000587260 ENSP00000467785
ENST00000591028 ENSP00000465094
ENST00000588680
ENST00000586873 ENSP00000468707
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 12 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006260 DNA replication
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0021549 cerebellum development
GO:0021680 cerebellar Purkinje cell layer development
GO:0021707 cerebellar granule cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048708 astrocyte differentiation
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
RNA Polymerase III Transcription Termination pathway
RNA Polymerase III Transcription pathway
RNA Polymerase III Abortive And Retractive Initiation pathway
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
Gene Expression pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.597451 Hs.619048 Hs.621701
RefSeq NM_001271043 NM_001271044 NM_002501 XM_006722760
HUGO
OMIM
CCDS CCDS45996 CCDS59359
HPRD 01234
IMGT
EMBL
GenPept
RNA Seq Atlas