Version 5.4
Homo sapiens Gene: MEF2A
Summary
InnateDB Gene IDBG-31725.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MEF2A
Gene Name myocyte enhancer factor 2A
Synonyms ADCAD1; mef2; RSRFC4; RSRFC9
Species Homo sapiens
Ensembl Gene ENSG00000068305
Encoded Proteins
IDBP-31727
myocyte enhancer factor 2A
IDBP-31731
myocyte enhancer factor 2A
IDBP-381027
myocyte enhancer factor 2A
IDBP-589771
myocyte enhancer factor 2A
IDBP-588360
myocyte enhancer factor 2A
IDBP-597028
myocyte enhancer factor 2A
IDBP-600645
myocyte enhancer factor 2A
IDBP-583899
myocyte enhancer factor 2A
IDBP-602653
myocyte enhancer factor 2A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. The encoded protein can act as a homodimer or as a heterodimer and is involved in several cellular processes, including muscle development, neuronal differentiation, cell growth control, and apoptosis. Defects in this gene could be a cause of autosomal dominant coronary artery disease 1 with myocardial infarction (ADCAD1). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:99565417-99716466
Strand Forward strand
Band q26.3
Transcripts
ENST00000338042 ENSP00000337202
ENST00000354410 ENSP00000346389
ENST00000449277 ENSP00000399460
ENST00000560493 ENSP00000453478
ENST00000558856
ENST00000558812 ENSP00000454120
ENST00000559036
ENST00000558983
ENST00000557785 ENSP00000453441
ENST00000558049 ENSP00000454023
ENST00000557942 ENSP00000453095
ENST00000559903 ENSP00000452989
ENST00000561125
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 49 [view]
Protein-Protein 45 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001085 RNA polymerase II transcription factor binding
GO:0001105 RNA polymerase II transcription coactivator activity
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0033613 activating transcription factor binding
GO:0035035 histone acetyltransferase binding
GO:0042826 histone deacetylase binding
GO:0043565 sequence-specific DNA binding
GO:0046332 SMAD binding
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
Biological Process
GO:0000002 mitochondrial genome maintenance
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000165 MAPK cascade
GO:0002224 toll-like receptor signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006915 apoptotic process
GO:0007507 heart development
GO:0007517 muscle organ development
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034146 toll-like receptor 5 signaling pathway
GO:0034162 toll-like receptor 9 signaling pathway
GO:0034166 toll-like receptor 10 signaling pathway
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway
GO:0042692 muscle cell differentiation
GO:0045087 innate immune response
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048311 mitochondrion distribution
GO:0048813 dendrite morphogenesis
GO:0051149 positive regulation of muscle cell differentiation
GO:0051403 stress-activated MAPK cascade
GO:0055005 ventricular cardiac myofibril assembly
GO:0061337 cardiac conduction
GO:0070375 ERK5 cascade
GO:0071277 cellular response to calcium ion
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030557
View Gene Order
ENSBTAG00000010649
Not yet available
Pathways
NETPATH
NetPath_7
TGF_beta_Receptor pathway
REACTOME
REACT_12599
ERK/MAPK targets pathway
REACT_6809
MyD88-independent cascade pathway
REACT_6783
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_6788
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_8005
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_8006
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_25024
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_25222
MyD88 dependent cascade initiated on endosome pathway
REACT_9047
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_27215
MyD88 cascade initiated on plasma membrane pathway
REACT_9027
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_9061
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_21402
CDO in myogenesis pathway
REACT_111045
Developmental Biology pathway
REACT_11061
Signalling by NGF pathway
REACT_9020
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_6802
Innate Immune System pathway
REACT_7980
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_111102
Signal Transduction pathway
REACT_21308
MAP kinase activation in TLR cascade pathway
REACT_21303
Myogenesis pathway
REACT_6900
Immune System pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_6890
Activated TLR4 signalling pathway
REACT_12433
Nuclear Events (kinase and transcription factor activation) pathway
REACT_21328
MAPK targets/ Nuclear events mediated by MAP kinases pathway
REACT_25281
TRIF-mediated TLR3/TLR4 signaling pathway
KEGG
INOH
PID NCI
p38alphabetadownstreampathway
Signaling mediated by p38-alpha and p38-beta
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.268675 Hs.714448
RefSeq NM_001130926 NM_001130927 NM_001130928 NM_001171894 NM_005587 XM_005254914 XM_005254915 XM_006720509 XM_006720510 XM_006720511 XM_006720512 XM_006720513 XM_006720514 XM_006720515 XM_006720516 XM_006720517 XM_006720518
HUGO
OMIM
CCDS CCDS45362 CCDS45363 CCDS53978 CCDS58401
HPRD 02807
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca