Version 5.4
Homo sapiens Gene: SLC25A32
Summary
InnateDB Gene IDBG-31746.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC25A32
Gene Name solute carrier family 25 (mitochondrial folate carrier) , member 32
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000164933
Encoded Proteins
IDBP-31748
solute carrier family 25, member 32
IDBP-479138
solute carrier family 25, member 32
IDBP-475978
solute carrier family 25, member 32
IDBP-482171
solute carrier family 25, member 32
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the P(I/L)W subfamily of mitochondrial carrier family transport proteins. The encoded protein transports folate across the inner mitochondrial membrane. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:103398635-103415189
Strand Reverse strand
Band q22.3
Transcripts
ENST00000297578 ENSP00000297578
ENST00000521645 ENSP00000430989
ENST00000523256 ENSP00000427737
ENST00000523866 ENSP00000430371
ENST00000523701
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008517 folic acid transporter activity
Biological Process
GO:0006766 vitamin metabolic process
GO:0006767 water-soluble vitamin metabolic process
GO:0006810 transport
GO:0006839 mitochondrial transport
GO:0015884 folic acid transport
GO:0044281 small molecule metabolic process
GO:0046655 folic acid metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022299
View Gene Order
ENSBTAG00000033902
Not yet available
Pathways
NETPATH
REACTOME
REACT_11167
Metabolism of folate and pterines pathway
REACT_169312
Defective HLCS causes multiple carboxylase deficiency pathway
REACT_169313
Defective MUT causes methylmalonic aciduria mut type pathway
REACT_169316
Defective MMAA causes methylmalonic aciduria type cblA pathway
REACT_169120
Defective TCN2 causes hereditary megaloblastic anemia pathway
REACT_11238
Metabolism of water-soluble vitamins and cofactors pathway
REACT_169280
Defective AMN causes hereditary megaloblastic anemia 1 pathway
REACT_169149
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG pathway
REACT_169363
Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF pathway
REACT_169178
Defective CD320 causes methylmalonic aciduria pathway
REACT_169429
Defects in cobalamin (B12) metabolism pathway
REACT_169169
Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC pathway
REACT_169238
Defects in biotin (Btn) metabolism pathway
REACT_169403
Defective BTD causes biotidinase deficiency pathway
REACT_169415
Defective GIF causes intrinsic factor deficiency pathway
REACT_169385
Defects in vitamin and cofactor metabolism pathway
REACT_169132
Defective CUBN causes hereditary megaloblastic anemia 1 pathway
REACT_169256
Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD pathway
REACT_169439
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE pathway
REACT_111217
Metabolism pathway
REACT_169318
Defective MMAB causes methylmalonic aciduria type cblB pathway
REACT_116125
Disease pathway
REACT_11193
Metabolism of vitamins and cofactors pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9H2D1
TrEMBL A0A024R9D0 B4DUQ5 E5RFL3 E5RGK5 E5RGT9
UniProt Splice Variant
Entrez Gene 81034
UniGene Hs.607819 Hs.719537
RefSeq NM_030780
HUGO HGNC:29683
OMIM 610815
CCDS CCDS6300
HPRD
IMGT
EMBL AC012213 AF283645 AK027531 AK027787 AK300748 BC021893 CH471060
GenPept AAG37834 AAH21893 BAB55180 BAB55368 BAG62417 EAW91877 EAW91878
RNA Seq Atlas 81034

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca