Version 5.4
Homo sapiens Gene: ATG10
Summary
InnateDB Gene IDBG-32027.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATG10
Gene Name autophagy related 10
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000152348
Encoded Proteins
IDBP-32031
ATG10 autophagy related 10 homolog (S. cerevisiae)
IDBP-32033
ATG10 autophagy related 10 homolog (S. cerevisiae)
IDBP-372863
ATG10 autophagy related 10 homolog (S. cerevisiae)
IDBP-473644
ATG10 autophagy related 10 homolog (S. cerevisiae)
IDBP-478898
ATG10 autophagy related 10 homolog (S. cerevisiae)
IDBP-482211
ATG10 autophagy related 10 homolog (S. cerevisiae)
IDBP-482855
ATG10 autophagy related 10 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Autophagy is a process for the bulk degradation of cytosolic compartments by lysosomes. ATG10 is an E2-like enzyme involved in 2 ubiquitin-like modifications essential for autophagosome formation: ATG12 (MIM 609608)-ATG5 (MIM 604261) conjugation and modification of a soluble form of MAP-LC3 (MAP1LC3A; MIM 601242), a homolog of yeast Apg8, to a membrane-bound form (Nemoto et al., 2003 [PubMed 12890687]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:81972025-82276857
Strand Forward strand
Band q14.1
Transcripts
ENST00000355178 ENSP00000347309
ENST00000282185 ENSP00000282185
ENST00000458350 ENSP00000404938
ENST00000510085 ENSP00000422340
ENST00000513443 ENSP00000425182
ENST00000504770 ENSP00000424236
ENST00000513634 ENSP00000425225
ENST00000508814
ENST00000514253
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019777 Atg12 ligase activity
Biological Process
GO:0006497 protein lipidation
GO:0006914 autophagy
GO:0015031 protein transport
GO:0031401 positive regulation of protein modification process
GO:0032446 protein modification by small protein conjugation
GO:0034263 autophagy in response to ER overload
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021619
View Gene Order
ENSBTAG00000038117
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04140
Regulation of autophagy pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.658622 Hs.678105
RefSeq NM_001131028 NM_031482 XM_005248610 XM_005248611
HUGO
OMIM
CCDS CCDS4057
HPRD 16497
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca