Homo sapiens Gene: FBXW12
InnateDB Gene IDBG-32446.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FBXW12
Gene Name F-box and WD repeat domain containing 12
Species Homo sapiens
Ensembl Gene ENSG00000164049
Encoded Proteins
F-box and WD repeat domain containing 12
F-box and WD repeat domain containing 12
F-box and WD repeat domain containing 12
F-box and WD repeat domain containing 12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Members of the F-box protein family, such as FBXW12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:48372219-48401259
Strand Forward strand
Band p21.31
ENST00000296438 ENSP00000296438
ENST00000445170 ENSP00000406139
ENST00000415155 ENSP00000414683
ENST00000436231 ENSP00000413866
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
No orthologs found for this gene
SwissProt Q6X9E4
UniProt Splice Variant
Entrez Gene 285231
UniGene Hs.288793
RefSeq NM_001159927 NM_207102 NM_001159929
OMIM 609075
CCDS CCDS54578 CCDS2764 CCDS54577
HPRD 16428
EMBL AC104448 AY247969 BC101304 BC101305
GenPept AAI01305 AAI01306 AAP75562
RNA Seq Atlas 285231