InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CENPE

Summary

InnateDB Gene

IDBG-32488.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CENPE

Gene Name

centromere protein E, 312kDa

Synonyms

CENP-E; KIF10; PPP1R61

Species

Homo sapiens

Ensembl Gene

ENSG00000138778

Encoded Proteins

IDBP-32490

centromere protein E, 312kDa

IDBP-32492

centromere protein E, 312kDa

IDBP-473874

centromere protein E, 312kDa

IDBP-478124

centromere protein E, 312kDa

IDBP-812826

centromere protein E, 312kDa

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Centrosome-associated protein E is a kinesin-like motor protein that accumulates in the G2 phase of the cell cycle. Unlike other centrosome-associated proteins, it is not present during interphase and first appears at the centromere region of chromosomes during prometaphase. CENPE is proposed to be one of the motors responsible for mammalian chromosome movement and/or spindle elongation. [provided by RefSeq, Jul 2008]
Centrosome-associated protein E is a kinesin-like motor protein that accumulates in the G2 phase of the cell cycle. Unlike other centrosome-associated proteins, it is not present during interphase and first appears at the centromere region of chromosomes during prometaphase. CENPE is proposed to be one of the motors responsible for mammalian chromosome movement and/or spindle elongation. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:103105806-103198409

Strand

Reverse strand

Band

q24

Transcripts

ENST00000265148	ENSP00000265148
ENST00000380026	ENSP00000369365
ENST00000509823
ENST00000515478
ENST00000503705	ENSP00000423981
ENST00000509120
ENST00000514974	ENSP00000426023
ENST00000611174	ENSP00000483542

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	28 [view]
Protein-Protein	24 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003777	microtubule motor activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0005525	GTP binding
GO:0008017	microtubule binding
GO:0043515	kinetochore binding

Biological Process

GO:0000089	mitotic metaphase
GO:0000278	mitotic cell cycle
GO:0006355	regulation of transcription, DNA-templated
GO:0006614	SRP-dependent cotranslational protein targeting to membrane
GO:0007018	microtubule-based movement
GO:0007079	mitotic chromosome movement towards spindle pole
GO:0007080	mitotic metaphase plate congression
GO:0007165	signal transduction
GO:0007275	multicellular organismal development
GO:0007596	blood coagulation
GO:0008152	metabolic process
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0045860	positive regulation of protein kinase activity
GO:0051382	kinetochore assembly

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0000776	kinetochore
GO:0000778	condensed nuclear chromosome kinetochore
GO:0000779	condensed chromosome, centromeric region
GO:0000940	condensed chromosome outer kinetochore
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005819	spindle
GO:0005829	cytosol
GO:0005871	kinesin complex
GO:0005874	microtubule
GO:0015630	microtubule cytoskeleton
GO:0016020	membrane