Homo sapiens Gene: ATF1
Summary
InnateDB Gene IDBG-32838.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATF1
Gene Name activating transcription factor 1
Synonyms EWS-ATF1; FUS/ATF-1; TREB36;
Species Homo sapiens
Ensembl Gene ENSG00000123268
Encoded Proteins
activating transcription factor 1
activating transcription factor 1
activating transcription factor 1
activating transcription factor 1
activating transcription factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6. [provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:50763710-50821122
Strand Forward strand
Band q13.12
Transcripts
ENST00000262053 ENSP00000262053
ENST00000552510 ENSP00000448592
ENST00000549612 ENSP00000448421
ENST00000551831 ENSP00000448987
ENST00000552487 ENSP00000448921
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
Experimentally validated
Total 29 [view]
Protein-Protein 20 [view]
Protein-DNA 9 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0032403 protein complex binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0002224 toll-like receptor signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0010976 positive regulation of neuron projection development
GO:0014070 response to organic cyclic compound
GO:0032025 response to cobalt ion
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034146 toll-like receptor 5 signaling pathway
GO:0034162 toll-like receptor 9 signaling pathway
GO:0034166 toll-like receptor 10 signaling pathway
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway
GO:0043623 cellular protein complex assembly
GO:0045087 innate immune response
GO:0045740 positive regulation of DNA replication
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0051403 stress-activated MAPK cascade
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
IL3 pathway
Leptin pathway
IL11 pathway
REACTOME
MyD88 dependent cascade initiated on endosome pathway
Signalling by NGF pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
CREB phosphorylation pathway
MyD88 cascade initiated on plasma membrane pathway
Innate Immune System pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
Signal Transduction pathway
MAP kinase activation in TLR cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Immune System pathway
MyD88-independent cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
NGF signalling via TRKA from the plasma membrane pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Activated TLR4 signalling pathway
Nuclear Events (kinase and transcription factor activation) pathway
MAPK targets/ Nuclear events mediated by MAP kinases pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
KEGG
INOH
PID BIOCARTA
Tnf/stress related signaling [Biocarta view]
PID NCI
ErbB1 downstream signaling
Signaling mediated by p38-alpha and p38-beta
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.648565
RefSeq NM_005171
HUGO
OMIM
CCDS CCDS8803
HPRD 00440
IMGT
EMBL
GenPept
RNA Seq Atlas