Version 5.4
Homo sapiens Gene: COPS3
Summary
InnateDB Gene IDBG-32911.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol COPS3
Gene Name COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)
Synonyms CSN3; SGN3
Species Homo sapiens
Ensembl Gene ENSG00000141030
Encoded Proteins
IDBP-32913
COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)
IDBP-370929
COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)
IDBP-370930
COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)
IDBP-762672
IDBP-760191
IDBP-760973
IDBP-588950
COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)
IDBP-762853
IDBP-759111
IDBP-758246
IDBP-759473
IDBP-761749
IDBP-760554
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:17246820-17281293
Strand Reverse strand
Band p11.2
Transcripts
ENST00000268717 ENSP00000268717
ENST00000417352 ENSP00000409028
ENST00000439936 ENSP00000413298
ENST00000486032
ENST00000463097
ENST00000471414
ENST00000486810
ENST00000492672 ENSP00000463477
ENST00000477299 ENSP00000463195
ENST00000495640 ENSP00000465156
ENST00000462236
ENST00000539941 ENSP00000437606
ENST00000577246 ENSP00000464369
ENST00000584216 ENSP00000463098
ENST00000579716 ENSP00000466153
ENST00000577210 ENSP00000463340
ENST00000583160 ENSP00000468536
ENST00000578317 ENSP00000464572
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 96 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 96 [view]
Protein-Protein 93 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001701 in utero embryonic development
GO:0007165 signal transduction
GO:0009416 response to light stimulus
GO:0010388 cullin deneddylation
Cellular Component
GO:0005737 cytoplasm
GO:0008180 COP9 signalosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000019373
View Gene Order
ENSBTAG00000018973
Not yet available
Pathways
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.6076
RefSeq NM_001199125 NM_003653 XM_005256837 XM_005256838 XM_005256839 XM_005256840 XM_005256841
HUGO
OMIM
CCDS CCDS11183 CCDS56022
HPRD 07262
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca