InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TRIM56

Summary

InnateDB Gene

IDBG-32956.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRIM56

Gene Name

tripartite motif containing 56

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000169871

Encoded Proteins

IDBP-32958

tripartite motif containing 56

IDBP-384105

tripartite motif containing 56

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21074459

TRIM56 is a regulator of double-stranded DNA-mediated type I interferon induction where it acts as an interferon-inducible E3 ubiquitin ligase that modulates STING to confer double-stranded DNA-mediated innate immune responses.

PMID 21289118

TRIM56 is an anti-viral host factor that restricts pestivirus infection, specifically it was found to impair bovine viral diarrhoea virus replication.

PMID 22948160

TRIM56 is an essential component of the TLR3 anti-viral signalling pathway.

PMID 23438823

TRIM56 was identified in a systematic screen for positive regulators of innate immune responses.

InnateDB Annotation from Orthologs

Summary

PMID 21289118

[Mus musculus] Trim56 is an anti-viral host factor that restricts pestivirus infection, specifically it was found to impair bovine viral diarrhoea virus replication.

PMID 22948160

[Mus musculus] TRIM56 is an essential component of the TLR3 anti-viral signalling pathway. (Demonstrated in human)

Entrez Gene

Summary

Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:101085439-101091736

Strand

Forward strand

Band

q22.1

Transcripts

ENST00000306085	ENSP00000305161
ENST00000412507	ENSP00000404186
ENST00000467847
ENST00000487252

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0032479	regulation of type I interferon production
GO:0032481	positive regulation of type I interferon production
GO:0032608	interferon-beta production
GO:0034340	response to type I interferon
GO:0045087	innate immune response (InnateDB)
GO:0046597	negative regulation of viral entry into host cell
GO:0051607	defense response to virus
GO:0070534	protein K63-linked ubiquitination
GO:1902187	negative regulation of viral release from host cell

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005829	cytosol

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000043279

View Gene Order

ENSBTAG00000012038

Not yet available

Pathways

NETPATH

REACTOME

REACT_6802

Innate Immune System pathway

REACT_163977

Regulation of innate immune responses to cytosolic DNA pathway

REACT_6900

Immune System pathway

REACT_118823

Cytosolic sensors of pathogen-associated DNA pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.521092

RefSeq

NM_030961

HUGO

OMIM

CCDS

CCDS43625

HPRD

10284

IMGT

EMBL

GenPept

RNA Seq Atlas