Homo sapiens Gene: MLNR
Summary
InnateDB Gene IDBG-32987.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MLNR
Gene Name motilin receptor
Synonyms GPR38; MTLR1;
Species Homo sapiens
Ensembl Gene ENSG00000102539
Encoded Proteins
motilin receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal (GI) tract. The protein encoded by this gene is a motilin receptor which is a member of the G-protein coupled receptor 1 family. This member is a multi-pass transmembrane protein, and is an important therapeutic target for the treatment of hypomotility disorders. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:49220338-49222377
Strand Forward strand
Band q14.2
Transcripts
ENST00000218721 ENSP00000218721
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0016520 growth hormone-releasing hormone receptor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007586 digestion
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Class A/1 (Rhodopsin-like receptors) pathway
G alpha (q) signalling events pathway
Signaling by GPCR pathway
Peptide ligand-binding receptors pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
KEGG
Neuroactive ligand-receptor interaction pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.248126
RefSeq NM_001507
HUGO
OMIM
CCDS CCDS9414
HPRD 04197
IMGT
EMBL
GenPept
RNA Seq Atlas