Homo sapiens Gene: SETDB2
Summary
InnateDB Gene IDBG-33315.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SETDB2
Gene Name SET domain, bifurcated 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000136169
Encoded Proteins
SET domain, bifurcated 2
SET domain, bifurcated 2
SET domain, bifurcated 2
SET domain, bifurcated 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Proteins that contain a SET domain, such as SETDB2, modulate gene expression epigenetically through histone H3 (see MIM 601128) methylation. SETDB2 is likely a histone H3 methyltransferase, as it contains both the active site and flanking cysteine residues required for catalytic activity (Zhang et al., 2003 [PubMed 12754510]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:49444374-49495003
Strand Forward strand
Band q14.2
Transcripts
ENST00000317257 ENSP00000326477
ENST00000258672 ENSP00000258672
ENST00000354234 ENSP00000346175
ENST00000481439
ENST00000611815 ENSP00000482240
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 2 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0018024 histone-lysine N-methyltransferase activity
GO:0046974 histone methyltransferase activity (H3-K9 specific)
Biological Process
GO:0001947 heart looping
GO:0007059 chromosome segregation
GO:0007067 mitotic nuclear division
GO:0034968 histone lysine methylation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0051567 histone H3-K9 methylation
GO:0070986 left/right axis specification
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Lysine degradation pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001160308 NM_031915 XM_005266568 XM_005266570
HUGO
OMIM
CCDS CCDS53868 CCDS9417
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas