Homo sapiens Gene: SF3B14
Summary
InnateDB Gene IDBG-33356.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SF3B14
Gene Name Pre-mRNA branch site protein p14
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000115128
Encoded Proteins
Pre-mRNA branch site protein p14
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a 14 kDa protein subunit of the splicing factor 3b complex. Splicing factor 3b associates with both the U2 and U11/U12 small nuclear ribonucleoprotein complexes (U2 snRNP) of spliceosomes. This 14 kDa protein interacts directly with subunit 1 of the splicing factor 3b complex. This 14 kDa protein also interacts directly with the adenosine that carries out the first transesterification step of splicing at the pre-mRNA branch site. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:24067584-24076443
Strand Reverse strand
Band p23.3
Transcripts
ENST00000233468 ENSP00000233468
ENST00000478050
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 68 experimentally validated interaction(s) in this database.
Experimentally validated
Total 68 [view]
Protein-Protein 68 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0008380 RNA splicing
GO:0010467 gene expression
Cellular Component
GO:0005654 nucleoplasm
GO:0005689 U12-type spliceosomal complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
mRNA Splicing - Major Pathway pathway
mRNA Splicing - Minor Pathway pathway
Processing of Capped Intron-Containing Pre-mRNA pathway
mRNA Splicing pathway
Gene Expression pathway
KEGG
Spliceosome pathway
INOH
PID NCI
Cross-References
SwissProt Q9Y3B4
TrEMBL
UniProt Splice Variant
Entrez Gene 51639
UniGene
RefSeq NM_016047
HUGO HGNC:30096
OMIM 607835
CCDS CCDS1707
HPRD 09702
IMGT
EMBL AC008073 AF151868 AF161523 AF184213 AF401310 AK311908 BC015463 CH471053
GenPept AAD34105 AAF29138 AAG09698 AAH15463 AAK94041 AAY14664 BAG34849 EAX00767
RNA Seq Atlas 51639