Homo sapiens Gene: HADH
Summary
InnateDB Gene IDBG-33469.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HADH
Gene Name hydroxyacyl-CoA dehydrogenase
Synonyms HAD; HADH1; HADHSC; HCDH; HHF4; MSCHAD; SCHAD;
Species Homo sapiens
Ensembl Gene ENSG00000138796
Encoded Proteins
hydroxyacyl-CoA dehydrogenase
hydroxyacyl-CoA dehydrogenase
hydroxyacyl-CoA dehydrogenase
hydroxyacyl-CoA dehydrogenase
hydroxyacyl-CoA dehydrogenase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the 3-hydroxyacyl-CoA dehydrogenase gene family. The encoded protein functions in the mitochondrial matrix to catalyze the oxidation of straight-chain 3-hydroxyacyl-CoAs as part of the beta-oxidation pathway. Its enzymatic activity is highest with medium-chain-length fatty acids. Mutations in this gene cause one form of familial hyperinsulinemic hypoglycemia. The human genome contains a related pseudogene of this gene on chromosome 15. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:107989714-108035175
Strand Forward strand
Band q25
Transcripts
ENST00000309522 ENSP00000312288
ENST00000403312 ENSP00000385638
ENST00000511742 ENSP00000425254
ENST00000505878 ENSP00000425952
ENST00000507260
ENST00000510728
ENST00000515462
ENST00000514776
ENST00000603302 ENSP00000474560
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 9 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0050660 flavin adenine dinucleotide binding
GO:0051287 NAD binding
GO:0070403 NAD+ binding
Biological Process
GO:0006631 fatty acid metabolic process
GO:0006635 fatty acid beta-oxidation
GO:0009725 response to hormone
GO:0014823 response to activity
GO:0032868 response to insulin
GO:0042493 response to drug
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0046676 negative regulation of insulin secretion
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Metabolism of lipids and lipoproteins pathway
Beta oxidation of octanoyl-CoA to hexanoyl-CoA pathway
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA pathway
Beta oxidation of butanoyl-CoA to acetyl-CoA pathway
Mitochondrial Fatty Acid Beta-Oxidation pathway
Beta oxidation of hexanoyl-CoA to butanoyl-CoA pathway
mitochondrial fatty acid beta-oxidation of saturated fatty acids pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA pathway
Metabolism pathway
KEGG
Fatty acid elongation pathway
Fatty acid degradation pathway
Valine, leucine and isoleucine degradation pathway
Lysine degradation pathway
Tryptophan metabolism pathway
Butanoate metabolism pathway
INOH
Tryptophan degradation pathway
Butanoate metabolism pathway
Valine Leucine Isoleucine degradation pathway
PID BIOCARTA
PID NCI
FOXA2 and FOXA3 transcription factor networks
Cross-References
SwissProt Q16836
TrEMBL
UniProt Splice Variant
Entrez Gene 3033
UniGene Hs.438289 Hs.713095
RefSeq NM_005327 NM_001184705 XM_005262972
HUGO HGNC:4799
OMIM 601609
CCDS CCDS3678 CCDS54790
HPRD
IMGT
EMBL AC114733 AC118062 AF001902 AF001903 AF001904 AF095703 BC000306 X96752
GenPept AAB54008 AAB54009 AAB58153 AAD13581 AAH00306 AAY41050 CAA65528
RNA Seq Atlas 3033