Version 5.4
Homo sapiens Gene: HADH
Summary
InnateDB Gene IDBG-33469.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HADH
Gene Name hydroxyacyl-CoA dehydrogenase
Synonyms HAD; HADH1; HADHSC; HCDH; HHF4; MSCHAD; SCHAD
Species Homo sapiens
Ensembl Gene ENSG00000138796
Encoded Proteins
IDBP-33473
hydroxyacyl-CoA dehydrogenase
IDBP-295559
hydroxyacyl-CoA dehydrogenase
IDBP-477576
hydroxyacyl-CoA dehydrogenase
IDBP-480943
hydroxyacyl-CoA dehydrogenase
IDBP-809819
hydroxyacyl-CoA dehydrogenase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the 3-hydroxyacyl-CoA dehydrogenase gene family. The encoded protein functions in the mitochondrial matrix to catalyze the oxidation of straight-chain 3-hydroxyacyl-CoAs as part of the beta-oxidation pathway. Its enzymatic activity is highest with medium-chain-length fatty acids. Mutations in this gene cause one form of familial hyperinsulinemic hypoglycemia. The human genome contains a related pseudogene of this gene on chromosome 15. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:107989714-108035175
Strand Forward strand
Band q25
Transcripts
ENST00000309522 ENSP00000312288
ENST00000403312 ENSP00000385638
ENST00000511742 ENSP00000425254
ENST00000505878 ENSP00000425952
ENST00000507260
ENST00000510728
ENST00000515462
ENST00000514776
ENST00000603302 ENSP00000474560
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 9 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0050660 flavin adenine dinucleotide binding
GO:0051287 NAD binding
GO:0070403 NAD+ binding
Biological Process
GO:0006631 fatty acid metabolic process
GO:0006635 fatty acid beta-oxidation
GO:0009725 response to hormone
GO:0014823 response to activity
GO:0032868 response to insulin
GO:0042493 response to drug
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0046676 negative regulation of insulin secretion
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027984
View Gene Order
ENSBTAG00000002049
Not yet available
Pathways
NETPATH
REACTOME
REACT_1887
Beta oxidation of hexanoyl-CoA to butanoyl-CoA pathway
REACT_735
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA pathway
REACT_419
Beta oxidation of butanoyl-CoA to acetyl-CoA pathway
REACT_1697
Beta oxidation of octanoyl-CoA to hexanoyl-CoA pathway
REACT_1708
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_1473
Mitochondrial Fatty Acid Beta-Oxidation pathway
REACT_1541
mitochondrial fatty acid beta-oxidation of saturated fatty acids pathway
REACT_111217
Metabolism pathway
KEGG
hsa00280
Valine, leucine and isoleucine degradation pathway
hsa00650
Butanoate metabolism pathway
hsa00380
Tryptophan metabolism pathway
hsa00071
Fatty acid degradation pathway
hsa00062
Fatty acid elongation pathway
hsa00310
Lysine degradation pathway
INOH
INOH website
Tryptophan degradation pathway
INOH website
Butanoate metabolism pathway
INOH website
Valine Leucine Isoleucine degradation pathway
PID NCI
hnf3bpathway
FOXA2 and FOXA3 transcription factor networks
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.438289 Hs.713095
RefSeq NM_001184705 NM_005327 XM_005262972
HUGO
OMIM
CCDS CCDS3678 CCDS54790
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca