Homo sapiens Gene: GPR56
Summary
InnateDB Gene IDBG-33507.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPR56
Gene Name G protein-coupled receptor 56
Synonyms BFPP; BPPR; TM7LN4; TM7XN1;
Species Homo sapiens
Ensembl Gene ENSG00000205336
Encoded Proteins
G protein-coupled receptor 56
G protein-coupled receptor 56
G protein-coupled receptor 56
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the G protein-coupled receptor family. The protein contains 7 transmembrane domains and a mucin-like domain in the N-terminal region. The gene is implicated in the regulation of brain cortical patterning. The protein binds specifically to transglutaminase 2 in the extracellular space. Expression of this gene is downregulated in melanoma cell lines, and overexpression of this gene can suppress tumor growth and metastasis. Mutations in this gene result in bilateral frontoparietal polymicrogyria. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
This gene encodes a member of the G protein-coupled receptor family and regulates brain cortical patterning. The encoded protein binds specifically to transglutaminase 2, a component of tissue and tumor stroma implicated as an inhibitor of tumor progression. Mutations in this gene are associated with a brain malformation known as bilateral frontoparietal polymicrogyria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:57610652-57665580
Strand Forward strand
Band q21
Transcripts
ENST00000388813 ENSP00000373465
ENST00000456916 ENSP00000398034
ENST00000540164 ENSP00000444911
ENST00000565013 ENSP00000454364
ENST00000569154 ENSP00000456544
ENST00000566169 ENSP00000456263
ENST00000565770 ENSP00000456603
ENST00000568908 ENSP00000457456
ENST00000563414 ENSP00000456147
ENST00000569372 ENSP00000457979
ENST00000566508 ENSP00000454779
ENST00000561969 ENSP00000456002
ENST00000564729 ENSP00000455965
ENST00000567915 ENSP00000457063
ENST00000570044 ENSP00000456166
ENST00000567835 ENSP00000456794
ENST00000568618 ENSP00000454233
ENST00000569158 ENSP00000457635
ENST00000563445 ENSP00000457073
ENST00000564907 ENSP00000455245
ENST00000567702 ENSP00000456787
ENST00000569132
ENST00000568487
ENST00000565587 ENSP00000456781
ENST00000562414 ENSP00000456494
ENST00000566123 ENSP00000457143
ENST00000563007 ENSP00000454574
ENST00000562804
ENST00000562608
ENST00000568234 ENSP00000458014
ENST00000564912
ENST00000565539 ENSP00000457612
ENST00000569494 ENSP00000456362
ENST00000568531 ENSP00000456682
ENST00000568700
ENST00000563862 ENSP00000457806
ENST00000567553 ENSP00000455812
ENST00000568074 ENSP00000458087
ENST00000567154 ENSP00000456632
ENST00000569101 ENSP00000457953
ENST00000566187 ENSP00000457178
ENST00000568909 ENSP00000455215
ENST00000561782 ENSP00000455176
ENST00000568791 ENSP00000454321
ENST00000561833 ENSP00000458063
ENST00000568979 ENSP00000455553
ENST00000565338 ENSP00000457122
ENST00000562673
ENST00000568645 ENSP00000454879
ENST00000565505
ENST00000562631 ENSP00000455351
ENST00000562558 ENSP00000456620
ENST00000562003 ENSP00000454607
ENST00000566271 ENSP00000454855
ENST00000561696 ENSP00000455600
ENST00000561872
ENST00000562467 ENSP00000456256
ENST00000565314 ENSP00000456469
ENST00000565976 ENSP00000454933
ENST00000569531 ENSP00000457307
ENST00000564722 ENSP00000456599
ENST00000567397 ENSP00000455226
ENST00000566778 ENSP00000456796
ENST00000562682 ENSP00000456819
ENST00000568157 ENSP00000454289
ENST00000566888
ENST00000564338 ENSP00000457657
ENST00000569992
ENST00000564360 ENSP00000457223
ENST00000564103 ENSP00000457994
ENST00000563548 ENSP00000454263
ENST00000565391 ENSP00000456731
ENST00000566164 ENSP00000455074
ENST00000563374 ENSP00000455209
ENST00000564783 ENSP00000454490
ENST00000561988 ENSP00000456238
ENST00000562101
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0005518 collagen binding
GO:0050840 extracellular matrix binding
Biological Process
GO:0001525 angiogenesis
GO:0007155 cell adhesion
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0007266 Rho protein signal transduction
GO:0007267 cell-cell signaling
GO:0007420 brain development
GO:0008285 negative regulation of cell proliferation
GO:0010573 vascular endothelial growth factor production
GO:0021801 cerebral cortex radial glia guided migration
GO:0021819 layer formation in cerebral cortex
GO:0035025 positive regulation of Rho protein signal transduction
GO:0045785 positive regulation of cell adhesion
GO:0070528 protein kinase C signaling
GO:2001223 negative regulation of neuron migration
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
GO:0097451 glial limiting end-foot
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.513633
RefSeq NM_001145770 NM_001145771 NM_001145772 NM_001145773 NM_001145774 NM_001290143 NM_001290144 NM_005682 NM_201524 NM_201525 XM_005256237 XM_005256238 XM_005256239 XM_005256240 XM_005256241 XM_005256242 XM_005256243 XM_005256244 XM_005256245 XM_005256246 XM_005256247 XM_005256248 XM_005256249 XM_005256251 XM_005256252 XM_005256253 XM_005256254 XM_005256255 XM_006721338 XM_006721339 XM_006721340 XM_006721341 XM_006721342 XM_006721343 XM_006721344 XM_006721345 XM_006721346 XM_006721347
HUGO
OMIM
CCDS CCDS32460 CCDS32461 CCDS73893
HPRD 06824
IMGT
EMBL
GenPept
RNA Seq Atlas