InnateDB: Systems Biology of the Innate Immune Response

This gene encodes a member of the G protein-coupled receptor family. The protein contains 7 transmembrane domains and a mucin-like domain in the N-terminal region. The gene is implicated in the regulation of brain cortical patterning. The protein binds specifically to transglutaminase 2 in the extracellular space. Expression of this gene is downregulated in melanoma cell lines, and overexpression of this gene can suppress tumor growth and metastasis. Mutations in this gene result in bilateral frontoparietal polymicrogyria. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
This gene encodes a member of the G protein-coupled receptor family and regulates brain cortical patterning. The encoded protein binds specifically to transglutaminase 2, a component of tissue and tumor stroma implicated as an inhibitor of tumor progression. Mutations in this gene are associated with a brain malformation known as bilateral frontoparietal polymicrogyria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:57610652-57665580

Strand

Forward strand

Band

q21

Transcripts

ENST00000388813	ENSP00000373465
ENST00000456916	ENSP00000398034
ENST00000540164	ENSP00000444911
ENST00000565013	ENSP00000454364
ENST00000569154	ENSP00000456544
ENST00000566169	ENSP00000456263
ENST00000565770	ENSP00000456603
ENST00000568908	ENSP00000457456
ENST00000563414	ENSP00000456147
ENST00000569372	ENSP00000457979
ENST00000566508	ENSP00000454779
ENST00000561969	ENSP00000456002
ENST00000564729	ENSP00000455965
ENST00000567915	ENSP00000457063
ENST00000570044	ENSP00000456166
ENST00000567835	ENSP00000456794
ENST00000568618	ENSP00000454233
ENST00000569158	ENSP00000457635
ENST00000563445	ENSP00000457073
ENST00000564907	ENSP00000455245
ENST00000567702	ENSP00000456787
ENST00000569132
ENST00000568487
ENST00000565587	ENSP00000456781
ENST00000562414	ENSP00000456494
ENST00000566123	ENSP00000457143
ENST00000563007	ENSP00000454574
ENST00000562804
ENST00000562608
ENST00000568234	ENSP00000458014
ENST00000564912
ENST00000565539	ENSP00000457612
ENST00000569494	ENSP00000456362
ENST00000568531	ENSP00000456682
ENST00000568700
ENST00000563862	ENSP00000457806
ENST00000567553	ENSP00000455812
ENST00000568074	ENSP00000458087
ENST00000567154	ENSP00000456632
ENST00000569101	ENSP00000457953
ENST00000566187	ENSP00000457178
ENST00000568909	ENSP00000455215
ENST00000561782	ENSP00000455176
ENST00000568791	ENSP00000454321
ENST00000561833	ENSP00000458063
ENST00000568979	ENSP00000455553
ENST00000565338	ENSP00000457122
ENST00000562673
ENST00000568645	ENSP00000454879
ENST00000565505
ENST00000562631	ENSP00000455351
ENST00000562558	ENSP00000456620
ENST00000562003	ENSP00000454607
ENST00000566271	ENSP00000454855
ENST00000561696	ENSP00000455600
ENST00000561872
ENST00000562467	ENSP00000456256
ENST00000565314	ENSP00000456469
ENST00000565976	ENSP00000454933
ENST00000569531	ENSP00000457307
ENST00000564722	ENSP00000456599
ENST00000567397	ENSP00000455226
ENST00000566778	ENSP00000456796
ENST00000562682	ENSP00000456819
ENST00000568157	ENSP00000454289
ENST00000566888
ENST00000564338	ENSP00000457657
ENST00000569992
ENST00000564360	ENSP00000457223
ENST00000564103	ENSP00000457994
ENST00000563548	ENSP00000454263
ENST00000565391	ENSP00000456731
ENST00000566164	ENSP00000455074
ENST00000563374	ENSP00000455209
ENST00000564783	ENSP00000454490
ENST00000561988	ENSP00000456238
ENST00000562101

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005518	collagen binding
GO:0050840	extracellular matrix binding

Biological Process

GO:0001525	angiogenesis
GO:0007155	cell adhesion
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0007266	Rho protein signal transduction
GO:0007267	cell-cell signaling
GO:0007420	brain development
GO:0008285	negative regulation of cell proliferation
GO:0010573	vascular endothelial growth factor production
GO:0021801	cerebral cortex radial glia guided migration
GO:0021819	layer formation in cerebral cortex
GO:0035025	positive regulation of Rho protein signal transduction
GO:0045785	positive regulation of cell adhesion
GO:0070528	protein kinase C signaling
GO:2001223	negative regulation of neuron migration

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome
GO:0097451	glial limiting end-foot

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000031785

View Gene Order

Cross-References

SwissProt

TrEMBL

H3BNN3 H3BQW4 H3BRA1 H3BRB4 H3BS14 H3BSN3 H3BSN7 H3BSR1 H3BT88 H3BTD2 H3BTK9 H3BV72 H3BVE9

UniProt Splice Variant

Entrez Gene

9289

UniGene

Hs.513633

RefSeq

NM_001145770 NM_001145771 NM_001145772 NM_001145773 NM_001145774 NM_001290143 NM_001290144 NM_005682 NM_201524 NM_201525 XM_005256237 XM_005256238 XM_005256239 XM_005256240 XM_005256241 XM_005256242 XM_005256243 XM_005256244 XM_005256245 XM_005256246 XM_005256247 XM_005256248 XM_005256249 XM_005256251 XM_005256252 XM_005256253 XM_005256254 XM_005256255 XM_006721338 XM_006721339 XM_006721340 XM_006721341 XM_006721342 XM_006721343 XM_006721344 XM_006721345 XM_006721346 XM_006721347

HUGO

HGNC:4512

OMIM

604110

CCDS

CCDS32460 CCDS32461 CCDS73893

HPRD

06824

IMGT

EMBL

AC018552

GenPept

RNA Seq Atlas

9289