Version 5.4
Homo sapiens Gene: NUCB2
Summary
InnateDB Gene IDBG-33791.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NUCB2
Gene Name nucleobindin 2
Synonyms HEL-S-109; NEFA
Species Homo sapiens
Ensembl Gene ENSG00000070081
Encoded Proteins
IDBP-33793
nucleobindin 2
IDBP-367928
nucleobindin 2
IDBP-591169
nucleobindin 2
IDBP-599912
nucleobindin 2
IDBP-603125
nucleobindin 2
IDBP-588727
nucleobindin 2
IDBP-588050
nucleobindin 2
IDBP-601361
nucleobindin 2
IDBP-602476
nucleobindin 2
IDBP-583435
nucleobindin 2
IDBP-592601
nucleobindin 2
IDBP-588385
nucleobindin 2
IDBP-603017
nucleobindin 2
IDBP-596089
nucleobindin 2
IDBP-809095
nucleobindin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein with a suggested role in calcium level maintenance, eating regulation in the hypothalamus, and release of tumor necrosis factor from vascular endothelial cells. This protein binds calcium and has EF-folding domains. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:17208153-17349974
Strand Forward strand
Band p15.1
Transcripts
ENST00000323688 ENSP00000320168
ENST00000458064 ENSP00000408702
ENST00000528644 ENSP00000431136
ENST00000530527 ENSP00000435160
ENST00000533773 ENSP00000433542
ENST00000526120 ENSP00000436215
ENST00000533511
ENST00000533738 ENSP00000435558
ENST00000525637
ENST00000531172 ENSP00000435968
ENST00000529010 ENSP00000436455
ENST00000530964 ENSP00000431328
ENST00000529313 ENSP00000431334
ENST00000533926 ENSP00000433194
ENST00000527580 ENSP00000435787
ENST00000531242
ENST00000527735 ENSP00000432741
ENST00000532240
ENST00000620945
ENST00000622082 ENSP00000481959
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
Experimentally validated
Total 30 [view]
Protein-Protein 29 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005640 nuclear outer membrane
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030659
View Gene Order
ENSBTAG00000017468
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.654599
RefSeq NM_005013 XM_005252941 XM_005252942 XM_005252943 XM_005252944 XM_005252945 XM_005252947 XM_005252948 XM_006718239
HUGO
OMIM
CCDS CCDS41623
HPRD 09726
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca