Version 5.4
Homo sapiens Gene: TOP3A
Summary
InnateDB Gene IDBG-33849.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TOP3A
Gene Name topoisomerase (DNA) III alpha
Synonyms TOP3; ZGRF7
Species Homo sapiens
Ensembl Gene ENSG00000177302
Encoded Proteins
IDBP-33853
topoisomerase (DNA) III alpha
IDBP-764181
IDBP-759991
IDBP-757973
IDBP-595494
topoisomerase (DNA) III alpha
IDBP-762463
IDBP-760803
IDBP-760002
IDBP-764356
IDBP-763311
IDBP-761421
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus reducing the number of supercoils and altering the topology of DNA. This enzyme forms a complex with BLM which functions in the regulation of recombination in somatic cells. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:18271428-18315007
Strand Reverse strand
Band p11.2
Transcripts
ENST00000321105 ENSP00000321636
ENST00000493648 ENSP00000465014
ENST00000489131 ENSP00000465864
ENST00000469739
ENST00000477508
ENST00000461127 ENSP00000464338
ENST00000472959
ENST00000542570 ENSP00000442336
ENST00000583328
ENST00000584582 ENSP00000462136
ENST00000582122 ENSP00000466099
ENST00000581536 ENSP00000466641
ENST00000580713
ENST00000580095 ENSP00000462790
ENST00000584669
ENST00000582981 ENSP00000462378
ENST00000583804
ENST00000582230
ENST00000585031 ENSP00000464493
ENST00000584887
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
Experimentally validated
Total 36 [view]
Protein-Protein 34 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003916 DNA topoisomerase activity
GO:0003917 DNA topoisomerase type I activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0006265 DNA topological change
GO:0007126 meiotic nuclear division
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
GO:0016605 PML body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000002814
View Gene Order
ENSBTAG00000017087
Not yet available
Pathways
NETPATH
REACTOME
REACT_27271
Meiotic recombination pathway
REACT_115566
Cell Cycle pathway
REACT_111183
Meiosis pathway
KEGG
hsa03440
Homologous recombination pathway
INOH
PID NCI
fanconi_pathway
Fanconi anemia pathway
atm_pathway
ATM pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.592115
RefSeq NM_004618
HUGO
OMIM
CCDS CCDS11194
HPRD 03145
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca