Version 5.4
Homo sapiens Gene: GAR1
Summary
InnateDB Gene IDBG-33995.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GAR1
Gene Name GAR1 ribonucleoprotein homolog (yeast)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000109534
Encoded Proteins
IDBP-33997
GAR1 ribonucleoprotein homolog (yeast)
IDBP-241191
GAR1 ribonucleoprotein homolog (yeast)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA2 and NOLA3 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. These four H/ACA snoRNP proteins are also components of the telomerase complex. The encoded protein of this gene contains two glycine- and arginine-rich domains and is related to Saccharomyces cerevisiae Gar1p. Two splice variants have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:109815510-109824740
Strand Forward strand
Band q25
Transcripts
ENST00000226796 ENSP00000226796
ENST00000394631 ENSP00000378127
ENST00000506840
ENST00000503671
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
Experimentally validated
Total 25 [view]
Protein-Protein 24 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005261 cation channel activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0001522 pseudouridine synthesis
GO:0006364 rRNA processing
GO:0006812 cation transport
GO:0042254 ribosome biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0015030 Cajal body
GO:0031429 box H/ACA snoRNP complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028010
View Gene Order
ENSBTAG00000000748
Not yet available
Cross-References
SwissProt Q9NY12
TrEMBL A0A024RDJ3
UniProt Splice Variant
Entrez Gene 54433
UniGene Hs.606828
RefSeq NM_032993 XM_005263069 NM_018983
HUGO HGNC:14264
OMIM 606468
CCDS CCDS34050
HPRD 07569
IMGT
EMBL AJ276003 AY780787 BC003413 CH471057
GenPept AAH03413 AAV98357 CAB76563 EAX06253 EAX06254
RNA Seq Atlas 54433

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca