InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: COL14A1

Summary

InnateDB Gene

IDBG-34088.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

COL14A1

Gene Name

collagen, type XIV, alpha 1

Synonyms

UND

Species

Homo sapiens

Ensembl Gene

ENSG00000187955

Encoded Proteins

IDBP-34090

collagen, type XIV, alpha 1

IDBP-34092

collagen, type XIV, alpha 1

IDBP-34094

collagen, type XIV, alpha 1

IDBP-375803

collagen, type XIV, alpha 1

IDBP-375808

collagen, type XIV, alpha 1

IDBP-474158

collagen, type XIV, alpha 1

IDBP-482589

collagen, type XIV, alpha 1

IDBP-600134

collagen, type XIV, alpha 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes the alpha chain of type XIV collagen, a member of the FACIT (fibril-associated collagens with interrupted triple helices) collagen family. Type XIV collagen interacts with the fibril surface and is involved in the regulation of fibrillogenesis. [provided by RefSeq, Jan 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:120059780-120372036

Strand

Forward strand

Band

q24.12

Transcripts

ENST00000297848	ENSP00000297848
ENST00000247781	ENSP00000247781
ENST00000309791	ENSP00000311809
ENST00000434620	ENSP00000409461
ENST00000432943
ENST00000440844	ENSP00000403640
ENST00000498051	ENSP00000428851
ENST00000523142	ENSP00000429123
ENST00000537875	ENSP00000443974

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005201	extracellular matrix structural constituent
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0030674	protein binding, bridging
GO:0044822	poly(A) RNA binding

Biological Process

GO:0003229	ventricular cardiac muscle tissue development
GO:0016337	single organismal cell-cell adhesion
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0030199	collagen fibril organization
GO:0030574	collagen catabolic process
GO:0048873	homeostasis of number of cells within a tissue
GO:0061050	regulation of cell growth involved in cardiac muscle cell development

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005581	collagen trimer
GO:0005596	collagen type XIV
GO:0005614	interstitial matrix
GO:0005615	extracellular space
GO:0005788	endoplasmic reticulum lumen
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000022371

View Gene Order

ENSBTAG00000013369

Not yet available

Pathways

NETPATH

REACTOME

REACT_121139

Collagen biosynthesis and modifying enzymes pathway

REACT_150401

Collagen degradation pathway

REACT_118779

Extracellular matrix organization pathway

REACT_118572

Degradation of the extracellular matrix pathway

REACT_120729

Collagen formation pathway

KEGG

hsa04974

Protein digestion and absorption pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.409662 Hs.605554 Hs.705782

RefSeq

NM_021110 XM_005251059 XM_006716651

HUGO

OMIM

CCDS

CCDS34938

HPRD

00379

IMGT

EMBL

GenPept

RNA Seq Atlas