Version 5.4
Homo sapiens Gene: KRT86
Summary
InnateDB Gene IDBG-34354.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KRT86
Gene Name keratin, type II cuticular Hb6
Synonyms Hb1; HB6; hHb6; KRTHB1; KRTHB6; MNX
Species Homo sapiens
Ensembl Gene ENSG00000170442
Encoded Proteins
IDBP-34356
Keratin, type II cuticular Hb6
IDBP-603192
Keratin, type II cuticular Hb6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB1 and KRTHB3, is found primarily in the hair cortex. Mutations in this gene and KRTHB1 have been observed in patients with a rare dominant hair disease, monilethrix. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:52249300-52309163
Strand Forward strand
Band q13.13
Transcripts
ENST00000293525 ENSP00000293525
ENST00000423955 ENSP00000444533
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
Biological Process
Cellular Component
GO:0005615 extracellular space
GO:0005882 intermediate filament
GO:0045095 keratin filament
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000067614
View Gene Order
ENSBTAG00000013720
Not yet available
Cross-References
SwissProt O43790
TrEMBL Q8N120 Q8NFV1 Q9NSB0 U3KPR1
UniProt Splice Variant
Entrez Gene 3892
UniGene Hs.278658
RefSeq NM_002284 XM_005268866
HUGO HGNC:6463
OMIM 601928
CCDS CCDS41785
HPRD 03567
IMGT
EMBL AC021066 AC121757 AF416705 AJ000263 AY121753 AY123848 AY152544 BC069585 X99142 Y19211
GenPept AAH69585 AAM92877 AAM94951 AAN04663 AAN75226 CAA03979 CAA67579 CAB76831
RNA Seq Atlas 3892

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca