Version 5.4
Homo sapiens Gene: KRT85
Summary
InnateDB Gene IDBG-34426.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KRT85
Gene Name keratin 85
Synonyms ECTD4; Hb-5; HB5; hHb5; K85; KRTHB5
Species Homo sapiens
Ensembl Gene ENSG00000135443
Encoded Proteins
IDBP-34428
keratin 85
IDBP-595516
keratin 85
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:52360006-52367481
Strand Reverse strand
Band q13.13
Transcripts
ENST00000257901 ENSP00000257901
ENST00000544265 ENSP00000440240
ENST00000552537
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
Experimentally validated
Total 21 [view]
Protein-Protein 20 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
Biological Process
GO:0008544 epidermis development
Cellular Component
GO:0005615 extracellular space
GO:0005882 intermediate filament
GO:0045095 keratin filament
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.182507
RefSeq NM_001300810 NM_002283 XM_005268865
HUGO
OMIM
CCDS CCDS73472 CCDS8824
HPRD 04139
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca