Homo sapiens Gene: KREMEN1
Summary
InnateDB Gene IDBG-3462.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KREMEN1
Gene Name kringle containing transmembrane protein 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000183762
Encoded Proteins
kringle containing transmembrane protein 1
kringle containing transmembrane protein 1
kringle containing transmembrane protein 1
kringle containing transmembrane protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:29073078-29168333
Strand Forward strand
Band q12.1
Transcripts
ENST00000327813 ENSP00000331242
ENST00000400335 ENSP00000383189
ENST00000407188 ENSP00000385431
ENST00000453585 ENSP00000388228
ENST00000474001
ENST00000479755
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006952 defense response
GO:0007154 cell communication
GO:0016055 Wnt signaling pathway
GO:0060828 regulation of canonical Wnt signaling pathway
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
Wnt pathway
REACTOME
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
Signaling by Wnt pathway
Signal Transduction pathway
negative regulation of TCF-dependent signaling by WNT ligand antagonists pathway
TCF dependent signaling in response to WNT pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Disease pathway
KEGG
INOH
Wnt signaling pathway pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 83999
UniGene Hs.229335 Hs.623655
RefSeq NM_032045 NM_001039570
HUGO HGNC:17550
OMIM 609898
CCDS CCDS13849 CCDS43000
HPRD 11182
IMGT
EMBL
GenPept
RNA Seq Atlas 83999