Homo sapiens Gene: DTNB
Summary
InnateDB Gene IDBG-34662.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DTNB
Gene Name dystrobrevin, beta
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000138101
Encoded Proteins
dystrobrevin, beta
dystrobrevin, beta
dystrobrevin, beta
dystrobrevin, beta
dystrobrevin, beta
dystrobrevin, beta
dystrobrevin, beta
dystrobrevin, beta
dystrobrevin, beta
dystrobrevin, beta
dystrobrevin, beta
dystrobrevin, beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes dystrobrevin beta, a component of the dystrophin-associated protein complex (DPC). The DPC consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and dystrobrevin alpha and beta. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Dystrobrevin beta is thought to interact with syntrophin and the DP71 short form of dystrophin. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:25377198-25673647
Strand Reverse strand
Band p23.3
Transcripts
ENST00000288642 ENSP00000288642
ENST00000356599 ENSP00000349007
ENST00000349996 ENSP00000340957
ENST00000303659 ENSP00000306529
ENST00000398951 ENSP00000381924
ENST00000406818 ENSP00000384084
ENST00000404103 ENSP00000385482
ENST00000407661 ENSP00000385193
ENST00000407038 ENSP00000384767
ENST00000405222 ENSP00000384787
ENST00000407186 ENSP00000385784
ENST00000497476
ENST00000496972 ENSP00000444463
ENST00000488457
ENST00000489949
ENST00000479898
ENST00000498437
ENST00000482145
ENST00000481841
ENST00000485845
ENST00000486555
ENST00000489756
ENST00000493538
ENST00000493386
ENST00000472690
ENST00000474987
ENST00000473113
ENST00000495466
ENST00000460418
ENST00000486826
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
Cellular Component
GO:0005737 cytoplasm
GO:0045202 synapse
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt O60941
TrEMBL Q53SF9
UniProt Splice Variant
Entrez Gene 1838
UniGene Hs.307720 Hs.741106
RefSeq NM_001256308 NM_001256303 NM_001256304 NM_021907 NM_033147 NM_033148 NM_183360 NM_183361 XM_005264182 XM_005264183 XM_005264184 XM_006711960 XM_006711961 XM_006711962
HUGO HGNC:3058
OMIM 602415
CCDS CCDS58702 CCDS46233 CCDS46234 CCDS46235 CCDS46236 CCDS46237 CCDS74496
HPRD 09091
IMGT
EMBL AC010150 AC012074 AC019144 AC104699 AF022728 AF070567 AK301386 BC016655 BC049366 BT009805 CH471053 Y12712 Y15718 Y15719 Y15720 Y15721 Y15722
GenPept AAC05082 AAC28643 AAH16655 AAH49366 AAP88807 AAY24111 BAH13469 CAA73249 CAA75733 CAA75734 CAA75735 CAA75736 CAA75737 EAX00719 EAX00722
RNA Seq Atlas 1838