InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ORC5

Summary

InnateDB Gene

IDBG-34679.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ORC5

Gene Name

origin recognition complex, subunit 5

Synonyms

ORC5L; ORC5P; ORC5T; PPP1R117

Species

Homo sapiens

Ensembl Gene

ENSG00000164815

Encoded Proteins

IDBP-34681

origin recognition complex, subunit 5

IDBP-384771

origin recognition complex, subunit 5

IDBP-384773

origin recognition complex, subunit 5

IDBP-384774

origin recognition complex, subunit 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Oct 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:104126341-104208047

Strand

Reverse strand

Band

q22.2

Transcripts

ENST00000297431	ENSP00000297431
ENST00000422497	ENSP00000393208
ENST00000447452	ENSP00000395747
ENST00000448563	ENSP00000387465
ENST00000477223
ENST00000463152
ENST00000485726

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	43 [view]
Protein-Protein	43 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003674	molecular_function
GO:0003688	DNA replication origin binding
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006260	DNA replication
GO:0006270	DNA replication initiation

Cellular Component

GO:0000808	origin recognition complex
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005664	nuclear origin of replication recognition complex
GO:0005737	cytoplasm