Version 5.4
Homo sapiens Gene: ASXL2
Summary
InnateDB Gene IDBG-34785.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ASXL2
Gene Name additional sex combs like 2 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000143970
Encoded Proteins
IDBP-34787
additional sex combs like 2 (Drosophila)
IDBP-294740
additional sex combs like 2 (Drosophila)
IDBP-367409
additional sex combs like 2 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary ASXL2 is a human homolog of the Drosophila asx gene. Drosophila asx is an enhancer of trithorax (see MIM 159555) and polycomb (see MIM 610231) (ETP) gene that encodes a chromatin protein with dual functions in transcriptional activation and silencing (Katoh and Katoh, 2003 [PubMed 12888926]).[supplied by OMIM, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:25733753-25878516
Strand Reverse strand
Band p23.3
Transcripts
ENST00000336112 ENSP00000337250
ENST00000404843 ENSP00000383920
ENST00000435504 ENSP00000391447
ENST00000497092
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0042975 peroxisome proliferator activated receptor binding
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007507 heart development
GO:0007512 adult heart development
GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway
GO:0045600 positive regulation of fat cell differentiation
GO:0045672 positive regulation of osteoclast differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048704 embryonic skeletal system morphogenesis
GO:1900159 positive regulation of bone mineralization involved in bone maturation
GO:1902466 positive regulation of histone H3-K27 trimethylation
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037486
View Gene Order
ENSBTAG00000019983
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.119815 Hs.722329
RefSeq NM_018263 XM_006712039 XM_006712040
HUGO
OMIM
CCDS
HPRD 10676
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca