Version 5.4
Homo sapiens Gene: LNPEP
Summary
InnateDB Gene IDBG-34882.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LNPEP
Gene Name leucyl/cystinyl aminopeptidase
Synonyms CAP; IRAP; P-LAP; PLAP
Species Homo sapiens
Ensembl Gene ENSG00000113441
Encoded Proteins
IDBP-34886
leucyl/cystinyl aminopeptidase
IDBP-238863
leucyl/cystinyl aminopeptidase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:96935394-97037515
Strand Forward strand
Band q15
Transcripts
ENST00000231368 ENSP00000231368
ENST00000395784
ENST00000395770 ENSP00000379117
ENST00000474122
ENST00000473914
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 11 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004177 aminopeptidase activity
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
GO:0006508 proteolysis
GO:0007267 cell-cell signaling
GO:0007565 female pregnancy
GO:0030163 protein catabolic process
GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0061024 membrane organization
Cellular Component
GO:0005576 extracellular region
GO:0005622 intracellular
GO:0005765 lysosomal membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0031905 early endosome lumen
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000023845
View Gene Order
ENSBTAG00000019900
Not yet available
Pathways
NETPATH
NetPath_11
TCR pathway
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_111168
Endosomal/Vacuolar pathway pathway
REACT_147867
Translocation of GLUT4 to the plasma membrane pathway
REACT_111119
Antigen processing-Cross presentation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa04614
Renin-angiotensin system pathway
INOH
PID NCI
insulin_glucose_pathway
Insulin-mediated glucose transport
Cross-References
SwissProt Q9UIQ6
TrEMBL
UniProt Splice Variant
Entrez Gene 4012
UniGene Hs.527199 Hs.619474 Hs.621033 Hs.628728 Hs.629144 Hs.656905 Hs.725062 Hs.733775
RefSeq NM_005575 NM_175920
HUGO HGNC:6656
OMIM 151300
CCDS CCDS4087 CCDS43346
HPRD
IMGT
EMBL AB208883 AJ131023 AJ131025 AJ131026 AJ131027 AJ131028 AJ131029 AJ131030 AJ131031 AJ131032 AJ131033 AJ131034 AJ131035 AJ131036 AJ131037 AJ131038 AJ131039 D50810 U62768 U62769
GenPept AAB66672 AAB66673 BAA09436 BAD92120 CAB61646 CAB94753
RNA Seq Atlas 4012

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca