InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RAB10

Summary

InnateDB Gene

IDBG-34944.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAB10

Gene Name

RAB10, member RAS oncogene family

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000084733

Encoded Proteins

IDBP-34948

RAB10, member RAS oncogene family

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

RAB10 belongs to the RAS (see HRAS; MIM 190020) superfamily of small GTPases. RAB proteins localize to exocytic and endocytic compartments and regulate intracellular vesicle trafficking (Bao et al., 1998 [PubMed 9918381]).[supplied by OMIM, Mar 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:26034107-26137454

Strand

Forward strand

Band

p23.3

Transcripts

ENST00000264710	ENSP00000264710
ENST00000495146
ENST00000462003
ENST00000473035

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	34 [view]
Protein-Protein	31 [view]
Protein-DNA	1 [view]
Protein-RNA	2 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0019003	GDP binding
GO:0031489	myosin V binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0006893	Golgi to plasma membrane transport
GO:0006913	nucleocytoplasmic transport
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0007409	axonogenesis
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport
GO:0016197	endosomal transport
GO:0019882	antigen processing and presentation
GO:0030859	polarized epithelial cell differentiation
GO:0032869	cellular response to insulin stimulus
GO:0043001	Golgi to plasma membrane protein transport
GO:0045200	establishment of neuroblast polarity
GO:0061024	membrane organization
GO:0061467	basolateral protein localization
GO:0071786	endoplasmic reticulum tubular network organization
GO:0072659	protein localization to plasma membrane
GO:0097051	establishment of protein localization to endoplasmic reticulum membrane

Cellular Component

GO:0000145	exocyst
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005789	endoplasmic reticulum membrane
GO:0005794	Golgi apparatus
GO:0005802	trans-Golgi network
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0030659	cytoplasmic vesicle membrane
GO:0030670	phagocytic vesicle membrane
GO:0032593	insulin-responsive compartment
GO:0055037	recycling endosome
GO:0055038	recycling endosome membrane
GO:0070062	extracellular vesicular exosome
GO:0071782	endoplasmic reticulum tubular network
GO:0072372	primary cilium

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000020671

View Gene Order

ENSBTAG00000000985

Not yet available

Pathways

NETPATH

REACTOME

REACT_147867

Translocation of GLUT4 to the plasma membrane pathway

REACT_11123

Membrane Trafficking pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

P61026

TrEMBL

Q53SX4 Q53T70 Q9UL28

UniProt Splice Variant

Entrez Gene

10890

UniGene

Hs.467960 Hs.594674

RefSeq

NM_016131

HUGO

HGNC:9759

OMIM

612672

CCDS

CCDS1720

HPRD

IMGT

EMBL

AC011742 AC013449 AF086917 AF091032 AF106681 AF297660 AF498945 AK023223 AL136650 BC000896 CH471053 CR457303

GenPept

AAD43034 AAF00045 AAG13413 AAH00896 AAM21093 AAP97147 AAX93140 AAY24262 BAB14474 CAB66585 CAG33584 EAX00710 EAX00711

RNA Seq Atlas

10890