Version 5.4
Homo sapiens Gene: RNF139
Summary
InnateDB Gene IDBG-34973.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RNF139
Gene Name ring finger protein 139
Synonyms HRCA1; RCA1; TRC8
Species Homo sapiens
Ensembl Gene ENSG00000170881
Encoded Proteins
IDBP-34975
ring finger protein 139
IDBP-475834
ring finger protein 139
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:124474738-124487914
Strand Forward strand
Band q24.13
Transcripts
ENST00000303545 ENSP00000304051
ENST00000517684 ENSP00000429836
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
Experimentally validated
Total 20 [view]
Protein-Protein 19 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0004872 receptor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0019787 small conjugating protein ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0008285 negative regulation of cell proliferation
GO:0016567 protein ubiquitination
GO:0017148 negative regulation of translation
GO:0031396 regulation of protein ubiquitination
GO:0060628 regulation of ER to Golgi vesicle-mediated transport
GO:0070613 regulation of protein processing
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037075
View Gene Order
ENSBTAG00000020399
Not yet available
Cross-References
SwissProt
TrEMBL E5RH85
UniProt Splice Variant
Entrez Gene 11236
UniGene Hs.492751 Hs.743643
RefSeq NM_007218
HUGO HGNC:17023
OMIM 603046
CCDS CCDS6350
HPRD 04333
IMGT
EMBL AC090198
GenPept
RNA Seq Atlas 11236

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca