Version 5.4
Homo sapiens Gene: MST1
Summary
InnateDB Gene IDBG-35033.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MST1
Gene Name macrophage stimulating 1 (hepatocyte growth factor-like)
Synonyms D3F15S2; DNF15S2; HGFL; MSP; NF15S2
Species Homo sapiens
Ensembl Gene ENSG00000173531
Encoded Proteins
IDBP-377436
macrophage stimulating 1 (hepatocyte growth factor-like)
IDBP-377443
macrophage stimulating 1 (hepatocyte growth factor-like)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. Despite the presence of the serine protease domain, the encoded protein may not have any proteolytic activity. The receptor for this protein is RON tyrosine kinase, which upon activation stimulates ciliary motility of ciliated epithelial lung cells. This protein is secreted and cleaved to form an alpha chain and a beta chain bridged by disulfide bonds. [provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:49683947-49689501
Strand Reverse strand
Band p21.31
Transcripts
ENST00000449682 ENSP00000414287
ENST00000448220 ENSP00000394756
ENST00000479115
ENST00000492329
ENST00000488350
ENST00000493836
ENST00000484144
ENST00000481930
ENST00000484269
ENST00000498021
ENST00000497359
ENST00000480268
ENST00000494809
ENST00000468847
ENST00000489007
ENST00000484673
ENST00000492370
ENST00000494828
ENST00000490966
ENST00000481055
ENST00000491943
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 14 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0007283 spermatogenesis
GO:0007566 embryo implantation
GO:0008150 biological_process
GO:0030317 sperm motility
Cellular Component
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032591
View Gene Order
ENSBTAG00000011585
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
a6b1_a6b4_integrin_pathway
a6b1 and a6b4 Integrin signaling
foxopathway
FoxO family signaling
amb2_neutrophils_pathway
amb2 Integrin signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.512587
RefSeq NM_020998
HUGO
OMIM
CCDS CCDS33757
HPRD 00798
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca