Homo sapiens Gene: CYP4F2
Summary
InnateDB Gene IDBG-35066.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CYP4F2
Gene Name cytochrome P450, family 4, subfamily F, polypeptide 2
Synonyms CPF2;
Species Homo sapiens
Ensembl Gene ENSG00000186115
Encoded Proteins
cytochrome P450, family 4, subfamily F, polypeptide 2
cytochrome P450, family 4, subfamily F, polypeptide 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F11, is approximately 16 kb away. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:15878023-15898120
Strand Reverse strand
Band p13.12
Transcripts
ENST00000011989 ENSP00000011989
ENST00000221700 ENSP00000221700
ENST00000392846
ENST00000589654 ENSP00000467846
ENST00000587671 ENSP00000467443
ENST00000586927 ENSP00000465514
ENST00000592710
ENST00000608168
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0008392 arachidonic acid epoxygenase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0018685 alkane 1-monooxygenase activity
GO:0020037 heme binding
GO:0047057 vitamin-K-epoxide reductase (warfarin-sensitive) activity
GO:0050051 leukotriene-B4 20-monooxygenase activity
GO:0052869 arachidonic acid omega-hydroxylase activity
GO:0052871 alpha-tocopherol omega-hydroxylase activity
GO:0052872 tocotrienol omega-hydroxylase activity
Biological Process
GO:0000038 very long-chain fatty acid metabolic process
GO:0001676 long-chain fatty acid metabolic process
GO:0003091 renal water homeostasis
GO:0003095 pressure natriuresis
GO:0006690 icosanoid metabolic process
GO:0006691 leukotriene metabolic process
GO:0006805 xenobiotic metabolic process
GO:0008217 regulation of blood pressure
GO:0017144 drug metabolic process
GO:0019369 arachidonic acid metabolic process
GO:0019373 epoxygenase P450 pathway
GO:0030195 negative regulation of blood coagulation
GO:0032304 negative regulation of icosanoid secretion
GO:0032305 positive regulation of icosanoid secretion
GO:0036101 leukotriene B4 catabolic process
GO:0042360 vitamin E metabolic process
GO:0042371 vitamin K biosynthetic process
GO:0044281 small molecule metabolic process
GO:0055078 sodium ion homeostasis
GO:0055114 oxidation-reduction process
GO:0097267 omega-hydroxylase P450 pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0016324 apical plasma membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Metabolism of lipids and lipoproteins pathway
Arachidonic acid metabolism pathway
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) pathway
Cytochrome P450 - arranged by substrate type pathway
Synthesis of Leukotrienes (LT) and Eoxins (EX) pathway
Fatty acids pathway
Metabolism pathway
Biological oxidations pathway
Eicosanoids pathway
Miscellaneous substrates pathway
Phase 1 - Functionalization of compounds pathway
KEGG
Arachidonic acid metabolism pathway
INOH
Prostaglandin Leukotriene metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL K7EK90
UniProt Splice Variant
Entrez Gene 8529
UniGene Hs.558423
RefSeq NM_001082
HUGO HGNC:2645
OMIM 604426
CCDS CCDS12336
HPRD 05112
IMGT
EMBL AC004791 AC005336
GenPept
RNA Seq Atlas 8529