InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CYP4F2

Summary

InnateDB Gene

IDBG-35066.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYP4F2

Gene Name

cytochrome P450, family 4, subfamily F, polypeptide 2

Synonyms

CPF2

Species

Homo sapiens

Ensembl Gene

ENSG00000186115

Encoded Proteins

IDBP-34862

cytochrome P450, family 4, subfamily F, polypeptide 2

IDBP-35068

cytochrome P450, family 4, subfamily F, polypeptide 2

IDBP-761486

IDBP-760943

IDBP-765787

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F11, is approximately 16 kb away. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:15878023-15898120

Strand

Reverse strand

Band

p13.12

Transcripts

ENST00000011989	ENSP00000011989
ENST00000221700	ENSP00000221700
ENST00000392846
ENST00000589654	ENSP00000467846
ENST00000587671	ENSP00000467443
ENST00000586927	ENSP00000465514
ENST00000592710
ENST00000608168

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0008392	arachidonic acid epoxygenase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0018685	alkane 1-monooxygenase activity
GO:0020037	heme binding
GO:0047057	vitamin-K-epoxide reductase (warfarin-sensitive) activity
GO:0050051	leukotriene-B4 20-monooxygenase activity
GO:0052869	arachidonic acid omega-hydroxylase activity
GO:0052871	alpha-tocopherol omega-hydroxylase activity
GO:0052872	tocotrienol omega-hydroxylase activity

Biological Process

GO:0000038	very long-chain fatty acid metabolic process
GO:0001676	long-chain fatty acid metabolic process
GO:0003091	renal water homeostasis
GO:0003095	pressure natriuresis
GO:0006690	icosanoid metabolic process
GO:0006691	leukotriene metabolic process
GO:0006805	xenobiotic metabolic process
GO:0008217	regulation of blood pressure
GO:0017144	drug metabolic process
GO:0019369	arachidonic acid metabolic process
GO:0019373	epoxygenase P450 pathway
GO:0030195	negative regulation of blood coagulation
GO:0032304	negative regulation of icosanoid secretion
GO:0032305	positive regulation of icosanoid secretion
GO:0036101	leukotriene B4 catabolic process
GO:0042360	vitamin E metabolic process
GO:0042371	vitamin K biosynthetic process
GO:0044281	small molecule metabolic process
GO:0055078	sodium ion homeostasis
GO:0055114	oxidation-reduction process
GO:0097267	omega-hydroxylase P450 pathway