Version 5.4
Homo sapiens Gene: PIK3CG
Summary
InnateDB Gene IDBG-35338.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PIK3CG
Gene Name phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
Synonyms p110gamma; p120-PI3K; PI3CG; PI3K; PI3Kgamma; PIK3
Species Homo sapiens
Ensembl Gene ENSG00000105851
Encoded Proteins
IDBP-35340
phosphoinositide-3-kinase, catalytic, gamma polypeptide
IDBP-384956
phosphoinositide-3-kinase, catalytic, gamma polypeptide
IDBP-483898
phosphoinositide-3-kinase, catalytic, gamma polypeptide
IDBP-482336
phosphoinositide-3-kinase, catalytic, gamma polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 25022365
[Mus musculus] Rab8a interacts with Pik3cg to regulate Akt signalling generated by surface Tlr4.
Entrez Gene
Summary This gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. [provided by RefSeq, Jul 2008]
This gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:106865278-106907145
Strand Forward strand
Band q22.3
Transcripts
ENST00000359195 ENSP00000352121
ENST00000440650 ENSP00000392258
ENST00000496166 ENSP00000419260
ENST00000473541 ENSP00000417623
ENST00000466738
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 44 [view]
Protein-Protein 43 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005488 binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016303 1-phosphatidylinositol-3-kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0035004 phosphatidylinositol 3-kinase activity
GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:0046875 ephrin receptor binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
Biological Process
GO:0001525 angiogenesis
GO:0001816 cytokine production
GO:0002250 adaptive immune response
GO:0002407 dendritic cell chemotaxis
GO:0002675 positive regulation of acute inflammatory response
GO:0002679 respiratory burst involved in defense response
GO:0006468 protein phosphorylation
GO:0006644 phospholipid metabolic process
GO:0006661 phosphatidylinositol biosynthetic process
GO:0006897 endocytosis
GO:0006954 inflammatory response
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007596 blood coagulation
GO:0010818 T cell chemotaxis
GO:0010897 negative regulation of triglyceride catabolic process
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0030168 platelet activation
GO:0030593 neutrophil chemotaxis
GO:0032252 secretory granule localization
GO:0033628 regulation of cell adhesion mediated by integrin
GO:0035747 natural killer cell chemotaxis
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
GO:0042098 T cell proliferation
GO:0042110 T cell activation
GO:0043303 mast cell degranulation
GO:0043406 positive regulation of MAP kinase activity
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response
GO:0046854 phosphatidylinositol phosphorylation
GO:0048015 phosphatidylinositol-mediated signaling
GO:0051897 positive regulation of protein kinase B signaling
GO:0055118 negative regulation of cardiac muscle contraction
GO:0070527 platelet aggregation
GO:0072672 neutrophil extravasation
GO:0097284 hepatocyte apoptotic process
GO:2000270 negative regulation of fibroblast apoptotic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005942 phosphatidylinositol 3-kinase complex
GO:0005944 1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex
GO:0016020 membrane
GO:0042629 mast cell granule
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020573
View Gene Order
ENSBTAG00000020848
Not yet available
Pathways
NETPATH
NetPath_1
Alpha6Beta4Integrin pathway
NetPath_4
EGFR1 pathway
NetPath_12
BCR pathway
NetPath_14
IL2 pathway
NetPath_17
IL5 pathway
NetPath_56
Prolactin pathway
REACTOME
REACT_1695
GPVI-mediated activation cascade pathway
REACT_19290
G beta:gamma signalling through PI3Kgamma pathway
REACT_121025
Synthesis of PIPs at the plasma membrane pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_14797
Signaling by GPCR pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_19388
G-protein beta:gamma signalling pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_121175
PI Metabolism pathway
REACT_120870
Phospholipid metabolism pathway
REACT_111217
Metabolism pathway
REACT_604
Hemostasis pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04150
mTOR signaling pathway pathway
hsa05221
Acute myeloid leukemia pathway
hsa04370
VEGF signaling pathway pathway
hsa04664
Fc epsilon RI signaling pathway pathway
hsa05210
Colorectal cancer pathway
hsa05223
Non-small cell lung cancer pathway
hsa00562
Inositol phosphate metabolism pathway
hsa04012
ErbB signaling pathway pathway
hsa05211
Renal cell carcinoma pathway
hsa04210
Apoptosis pathway
hsa05218
Melanoma pathway
hsa05213
Endometrial cancer pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa05214
Glioma pathway
hsa05222
Small cell lung cancer pathway
hsa04070
Phosphatidylinositol signaling system pathway
hsa04910
Insulin signaling pathway pathway
hsa04662
B cell receptor signaling pathway pathway
hsa05215
Prostate cancer pathway
hsa04510
Focal adhesion pathway
hsa04660
T cell receptor signaling pathway pathway
hsa04620
Toll-like receptor signaling pathway pathway
hsa04630
Jak-STAT signaling pathway pathway
hsa04930
Type II diabetes mellitus pathway
hsa04650
Natural killer cell mediated cytotoxicity pathway
hsa05220
Chronic myeloid leukemia pathway
hsa05212
Pancreatic cancer pathway
hsa04666
Fc gamma R-mediated phagocytosis pathway
hsa04722
Neurotrophin signaling pathway pathway
hsa04062
Chemokine signaling pathway pathway
hsa05200
Pathways in cancer pathway
hsa04914
Progesterone-mediated oocyte maturation pathway
hsa04960
Aldosterone-regulated sodium reabsorption pathway
hsa05146
Amoebiasis pathway
hsa05100
Bacterial invasion of epithelial cells pathway
hsa05142
Chagas disease (American trypanosomiasis) pathway
hsa04380
Osteoclast differentiation pathway
hsa05145
Toxoplasmosis pathway
hsa04973
Carbohydrate digestion and absorption pathway
hsa05160
Hepatitis C pathway
INOH
INOH website
Inositol phosphate metabolism pathway
PID NCI
il8cxcr2_pathway
IL8- and CXCR2-mediated signaling events
il8cxcr1_pathway
IL8- and CXCR1-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.32942 Hs.602240 Hs.629361 Hs.684154
RefSeq NM_001282426 NM_001282427 NM_002649 XM_005250443 XM_006716027
HUGO
OMIM
CCDS CCDS5739
HPRD 03135
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca