Homo sapiens Gene: PIK3CG
Summary
InnateDB Gene IDBG-35338.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PIK3CG
Gene Name phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
Synonyms p110gamma; p120-PI3K; PI3CG; PI3K; PI3Kgamma; PIK3;
Species Homo sapiens
Ensembl Gene ENSG00000105851
Encoded Proteins
phosphoinositide-3-kinase, catalytic, gamma polypeptide
phosphoinositide-3-kinase, catalytic, gamma polypeptide
phosphoinositide-3-kinase, catalytic, gamma polypeptide
phosphoinositide-3-kinase, catalytic, gamma polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Rab8a interacts with Pik3cg to regulate Akt signalling generated by surface Tlr4.
Entrez Gene
Summary This gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. [provided by RefSeq, Jul 2008]
This gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:106865278-106907145
Strand Forward strand
Band q22.3
Transcripts
ENST00000359195 ENSP00000352121
ENST00000440650 ENSP00000392258
ENST00000496166 ENSP00000419260
ENST00000473541 ENSP00000417623
ENST00000466738
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 44 [view]
Protein-Protein 43 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005488 binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016303 1-phosphatidylinositol-3-kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0035004 phosphatidylinositol 3-kinase activity
GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:0046875 ephrin receptor binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
Biological Process
GO:0001525 angiogenesis
GO:0001816 cytokine production
GO:0002250 adaptive immune response
GO:0002407 dendritic cell chemotaxis
GO:0002675 positive regulation of acute inflammatory response
GO:0002679 respiratory burst involved in defense response
GO:0006468 protein phosphorylation
GO:0006644 phospholipid metabolic process
GO:0006661 phosphatidylinositol biosynthetic process
GO:0006897 endocytosis
GO:0006954 inflammatory response
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007596 blood coagulation
GO:0010818 T cell chemotaxis
GO:0010897 negative regulation of triglyceride catabolic process
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0030168 platelet activation
GO:0030593 neutrophil chemotaxis
GO:0032252 secretory granule localization
GO:0033628 regulation of cell adhesion mediated by integrin
GO:0035747 natural killer cell chemotaxis
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
GO:0042098 T cell proliferation
GO:0042110 T cell activation
GO:0043303 mast cell degranulation
GO:0043406 positive regulation of MAP kinase activity
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response
GO:0046854 phosphatidylinositol phosphorylation
GO:0048015 phosphatidylinositol-mediated signaling
GO:0051897 positive regulation of protein kinase B signaling
GO:0055118 negative regulation of cardiac muscle contraction
GO:0070527 platelet aggregation
GO:0072672 neutrophil extravasation
GO:0097284 hepatocyte apoptotic process
GO:2000270 negative regulation of fibroblast apoptotic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005942 phosphatidylinositol 3-kinase complex
GO:0005944 1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex
GO:0016020 membrane
GO:0042629 mast cell granule
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
Alpha6Beta4Integrin pathway
EGFR1 pathway
BCR pathway
IL2 pathway
IL5 pathway
Prolactin pathway
REACTOME
Metabolism of lipids and lipoproteins pathway
Synthesis of PIPs at the plasma membrane pathway
Signaling by GPCR pathway
Platelet activation, signaling and aggregation pathway
G-protein beta:gamma signalling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPVI-mediated activation cascade pathway
PI Metabolism pathway
Phospholipid metabolism pathway
Metabolism pathway
G beta:gamma signalling through PI3Kgamma pathway
Hemostasis pathway
KEGG
Inositol phosphate metabolism pathway
ErbB signaling pathway pathway
Chemokine signaling pathway pathway
Phosphatidylinositol signaling system pathway
mTOR signaling pathway pathway
Apoptosis pathway
VEGF signaling pathway pathway
Osteoclast differentiation pathway
Focal adhesion pathway
Toll-like receptor signaling pathway pathway
Jak-STAT signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
T cell receptor signaling pathway pathway
B cell receptor signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Fc gamma R-mediated phagocytosis pathway
Leukocyte transendothelial migration pathway
Neurotrophin signaling pathway pathway
Regulation of actin cytoskeleton pathway
Insulin signaling pathway pathway
Progesterone-mediated oocyte maturation pathway
Type II diabetes mellitus pathway
Aldosterone-regulated sodium reabsorption pathway
Carbohydrate digestion and absorption pathway
Bacterial invasion of epithelial cells pathway
Chagas disease (American trypanosomiasis) pathway
Toxoplasmosis pathway
Amoebiasis pathway
Hepatitis C pathway
Pathways in cancer pathway
Colorectal cancer pathway
Renal cell carcinoma pathway
Pancreatic cancer pathway
Endometrial cancer pathway
Glioma pathway
Prostate cancer pathway
Melanoma pathway
Chronic myeloid leukemia pathway
Acute myeloid leukemia pathway
Small cell lung cancer pathway
Non-small cell lung cancer pathway
INOH
Inositol phosphate metabolism pathway
PID BIOCARTA
PID NCI
IL8- and CXCR2-mediated signaling events
IL8- and CXCR1-mediated signaling events
Cross-References
SwissProt P48736
TrEMBL A0A024R720 E9PDN7 Q24M88
UniProt Splice Variant
Entrez Gene 5294
UniGene Hs.32942 Hs.602240 Hs.629361 Hs.684154
RefSeq NM_001282427 NM_001282426 NM_002649 XM_005250443 XM_006716027
HUGO HGNC:8978
OMIM 601232
CCDS CCDS5739
HPRD 03135
IMGT
EMBL AC005018 AF327656 AY496423 BC035683 CH236947 CH471070 X83368
GenPept AAG61115 AAH35683 AAQ96873 AAS75801 CAA58284 EAL24396 EAW83387 EAW83388 EAW83389
RNA Seq Atlas 5294