Homo sapiens Gene: GMPPB
Summary
InnateDB Gene IDBG-35367.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GMPPB
Gene Name GDP-mannose pyrophosphorylase B
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000173540
Encoded Proteins
GDP-mannose pyrophosphorylase B
GDP-mannose pyrophosphorylase B
GDP-mannose pyrophosphorylase B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is thought to encode a GDP-mannose pyrophosphorylase. The encoded protein catalyzes the conversion of mannose-1-phosphate and GTP to GDP-mannose, a reaction involved in the production of N-linked oligosaccharides. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:49716844-49723951
Strand Reverse strand
Band p21.31
Transcripts
ENST00000308375 ENSP00000309092
ENST00000308388 ENSP00000311130
ENST00000480687 ENSP00000418565
ENST00000481959
ENST00000495627
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004475 mannose-1-phosphate guanylyltransferase activity
GO:0005525 GTP binding
GO:0016779 nucleotidyltransferase activity
Biological Process
GO:0006488 dolichol-linked oligosaccharide biosynthetic process
GO:0009058 biosynthetic process
GO:0009298 GDP-mannose biosynthetic process
GO:0018279 protein N-linked glycosylation via asparagine
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Post-translational protein modification pathway
Synthesis of substrates in N-glycan biosythesis pathway
Asparagine N-linked glycosylation pathway
Synthesis of GDP-mannose pathway
Metabolism of proteins pathway
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway
KEGG
Fructose and mannose metabolism pathway
Amino sugar and nucleotide sugar metabolism pathway
INOH
Fructose Mannose metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.567903 Hs.609556 Hs.662118 Hs.686126
RefSeq NM_013334 NM_021971
HUGO
OMIM
CCDS CCDS2802 CCDS2803
HPRD 13589
IMGT
EMBL
GenPept
RNA Seq Atlas