Version 5.4
Homo sapiens Gene: AP1B1
Summary
InnateDB Gene IDBG-3567.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AP1B1
Gene Name adaptor-related protein complex 1, beta 1 subunit
Synonyms ADTB1; AP105A; BAM22; CLAPB2
Species Homo sapiens
Ensembl Gene ENSG00000100280
Encoded Proteins
IDBP-3569
adaptor-related protein complex 1, beta 1 subunit
IDBP-3573
adaptor-related protein complex 1, beta 1 subunit
IDBP-294695
adaptor-related protein complex 1, beta 1 subunit
IDBP-294693
adaptor-related protein complex 1, beta 1 subunit
IDBP-370758
adaptor-related protein complex 1, beta 1 subunit
IDBP-370763
adaptor-related protein complex 1, beta 1 subunit
IDBP-370764
adaptor-related protein complex 1, beta 1 subunit
IDBP-370766
adaptor-related protein complex 1, beta 1 subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as one of the large subunits of this complex and is a member of the adaptin protein family. This gene is a candidate meningioma gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:29327680-29423179
Strand Reverse strand
Band q12.2
Transcripts
ENST00000357586 ENSP00000350199
ENST00000317368 ENSP00000319361
ENST00000405198 ENSP00000384194
ENST00000402502 ENSP00000386071
ENST00000415447 ENSP00000387612
ENST00000432560 ENSP00000400065
ENST00000421126 ENSP00000400022
ENST00000415756 ENSP00000392735
ENST00000482818
ENST00000472057
ENST00000473606
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 62 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 62 [view]
Protein-Protein 61 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005488 binding
GO:0005515 protein binding
GO:0008565 protein transporter activity
GO:0019901 protein kinase binding
Biological Process
GO:0006886 intracellular protein transport
GO:0006892 post-Golgi vesicle-mediated transport
GO:0015031 protein transport
GO:0016032 viral process
GO:0016192 vesicle-mediated transport
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0050690 regulation of defense response to virus by virus
GO:0061024 membrane organization
Cellular Component
GO:0000139 Golgi membrane
GO:0005765 lysosomal membrane
GO:0005829 cytosol
GO:0030117 membrane coat
GO:0030131 clathrin adaptor complex
GO:0030659 cytoplasmic vesicle membrane
GO:0030665 clathrin-coated vesicle membrane
GO:0032588 trans-Golgi network membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000009090
View Gene Order
ENSBTAG00000001189
Not yet available
Pathways
NETPATH
REACTOME
REACT_121399
MHC class II antigen presentation pathway
REACT_11103
Nef mediated downregulation of MHC class I complex cell surface expression pathway
REACT_19287
Lysosome Vesicle Biogenesis pathway
REACT_19400
Golgi Associated Vesicle Biogenesis pathway
REACT_19187
Clathrin derived vesicle budding pathway
REACT_11235
trans-Golgi Network Vesicle Budding pathway
REACT_11149
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_6185
HIV Infection pathway
REACT_6835
The role of Nef in HIV-1 replication and disease pathogenesis pathway
REACT_6288
Host Interactions of HIV factors pathway
REACT_116125
Disease pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa04142
Lysosome pathway
INOH
PID NCI
era_genomic_pathway
Validated nuclear estrogen receptor alpha network
hnf3apathway
FOXA1 transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.368794
RefSeq NM_001127 NM_001166019 NM_145730
HUGO
OMIM
CCDS CCDS13855 CCDS13856 CCDS54515
HPRD 02541
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca