Homo sapiens Gene: F2RL3
Summary
InnateDB Gene IDBG-35882.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol F2RL3
Gene Name coagulation factor II (thrombin) receptor-like 3
Synonyms PAR4
Species Homo sapiens
Ensembl Gene ENSG00000127533
Encoded Proteins
coagulation factor II (thrombin) receptor-like 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
F2RL3 modulates inflammation in the lung where its activation stimulates IL6, IL8, and PTGER2 (prostaglandin E2) release from human respiratory epithelial cells.
Entrez Gene
Summary Coagulation factor II (thrombin) receptor-like 3 (F2RL3) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL3 is also a member of the protease-activated receptor family. F2RL3 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL3 is activated by thrombin and trypsin. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:16888860-16892606
Strand Forward strand
Band p13.11
Transcripts
ENST00000248076 ENSP00000248076
ENST00000599210 ENSP00000471518
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0015057 thrombin receptor activity
Biological Process
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007596 blood coagulation
GO:0009611 response to wounding
GO:0030168 platelet activation
GO:0045087 innate immune response (InnateDB)
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0060155 platelet dense granule organization
GO:0070493 thrombin receptor signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Thrombin signalling through proteinase activated receptors (PARs) pathway
G alpha (q) signalling events pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Peptide ligand-binding receptors pathway
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Platelet activation, signaling and aggregation pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
Hemostasis pathway
KEGG
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
PAR4-mediated thrombin signaling events
Cross-References
SwissProt Q96RI0
TrEMBL M0R0Y0
UniProt Splice Variant
Entrez Gene 9002
UniGene Hs.137574
RefSeq NM_003950 XM_005260139
HUGO HGNC:3540
OMIM 602779
CCDS CCDS12350
HPRD
IMGT
EMBL AC008737 AF055917 AF080214 AF384819 AY431102 BC074782
GenPept AAC25699 AAC28860 AAH74782 AAK61908 AAR08487
RNA Seq Atlas 9002