Homo sapiens Gene: SLC6A5
Summary
InnateDB Gene IDBG-35956.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC6A5
Gene Name solute carrier family 6 (neurotransmitter transporter, glycine), member 5
Synonyms GLYT-2; GLYT2; HKPX3; NET1;
Species Homo sapiens
Ensembl Gene ENSG00000165970
Encoded Proteins
solute carrier family 6 (neurotransmitter transporter, glycine), member 5
solute carrier family 6 (neurotransmitter transporter, glycine), member 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a sodium- and chloride-dependent glycine neurotransmitter transporter. This integral membrane glycoprotein is responsible for the clearance of extracellular glycine during glycine-mediated neurotransmission. This protein is found in glycinergic axons and maintains a high presynaptic pool of neurotransmitter at glycinergic synapses. Mutations in this gene cause hyperekplexia; a heterogenous neurological disorder characterized by exaggerated startle responses and neonatal apnea. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:20599400-20659285
Strand Forward strand
Band p15.1
Transcripts
ENST00000298923 ENSP00000298923
ENST00000525748 ENSP00000434364
ENST00000528440
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005328 neurotransmitter:sodium symporter activity
GO:0015375 glycine:sodium symporter activity
Biological Process
GO:0006810 transport
GO:0006836 neurotransmitter transport
GO:0007268 synaptic transmission
GO:0036233 glycine import
GO:0055085 transmembrane transport
GO:0060012 synaptic transmission, glycinergic
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Na+/Cl- dependent neurotransmitter transporters pathway
SLC-mediated transmembrane transport pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL J3KNC4
UniProt Splice Variant
Entrez Gene 9152
UniGene Hs.136557 Hs.530715 Hs.557957
RefSeq XM_005253225 NM_004211
HUGO HGNC:11051
OMIM 604159
CCDS CCDS7854
HPRD 08378
IMGT
EMBL AC090707
GenPept
RNA Seq Atlas 9152