Version 5.4
Homo sapiens Gene: NOL3
Summary
InnateDB Gene IDBG-36117.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NOL3
Gene Name nucleolar protein 3 (apoptosis repressor with CARD domain)
Synonyms ARC; FCM; MYP; NOP; NOP30
Species Homo sapiens
Ensembl Gene ENSG00000140939
Encoded Proteins
IDBP-36119
nucleolar protein 3 (apoptosis repressor with CARD domain)
IDBP-752636
IDBP-752958
IDBP-750698
IDBP-752515
IDBP-749949
IDBP-753473
IDBP-746638
IDBP-749985
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an anti-apoptotic protein that has been shown to down-regulate the enzyme activities of caspase 2, caspase 8 and tumor protein p53. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:67170154-67175735
Strand Forward strand
Band q22.1
Transcripts
ENST00000268605 ENSP00000268605
ENST00000568503
ENST00000563258 ENSP00000463698
ENST00000564053 ENSP00000457243
ENST00000565560 ENSP00000457732
ENST00000568086
ENST00000566871 ENSP00000455808
ENST00000565645
ENST00000564860 ENSP00000463685
ENST00000563439 ENSP00000454256
ENST00000564992 ENSP00000457720
ENST00000568146 ENSP00000454598
ENST00000568199
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 43 [view]
Protein-Protein 36 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 7 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0001666 response to hypoxia
GO:0006397 mRNA processing
GO:0006915 apoptotic process
GO:0008380 RNA splicing
GO:0010468 regulation of gene expression
GO:0014876 response to injury involved in regulation of muscle adaptation
GO:0042981 regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
Cellular Component
GO:0005622 intracellular
GO:0005730 nucleolus
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0016528 sarcoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000014776
View Gene Order
ENSBTAG00000003519
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001185057 NM_001276307 NM_001276309 NM_001276311 NM_001276312 NM_001276319 NM_003946 XM_005256217 XM_006721322 XM_006721323
HUGO
OMIM
CCDS CCDS42176 CCDS58473 CCDS61960
HPRD 05572
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca