Homo sapiens Gene: SEMA3B
Summary
InnateDB Gene IDBG-36203.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SEMA3B
Gene Name sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
Synonyms LUCA-1; SemA; SEMA5; SEMAA; semaV;
Species Homo sapiens
Ensembl Gene ENSG00000012171
Encoded Proteins
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The semaphorin/collapsin family of molecules plays a critical role in the guidance of growth cones during neuronal development. The secreted protein encoded by this gene family member is important in axonal guidance and has been shown to act as a tumor suppressor by inducing apoptosis. [provided by RefSeq, Jul 2008]
The protein encoded by this gene belongs to the class-3 semaphorin/collapsin family, whose members function in growth cone guidance during neuronal development. This family member inhibits axonal extension and has been shown to act as a tumor suppressor by inducing apoptosis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:50267558-50277546
Strand Forward strand
Band p21.31
Transcripts
ENST00000441915
ENST00000439487
ENST00000434030
ENST00000456210
ENST00000456560 ENSP00000485646
ENST00000418576 ENSP00000485173
ENST00000419007
ENST00000433753 ENSP00000485281
ENST00000416295
ENST00000621029 ENSP00000482586
ENST00000619119
ENST00000616701 ENSP00000484146
ENST00000612509
ENST00000611067 ENSP00000480680
ENST00000618865 ENSP00000481957
ENST00000611418 ENSP00000484583
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
Biological Process
GO:0007267 cell-cell signaling
GO:0007275 multicellular organismal development
GO:0007411 axon guidance
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
Axon guidance pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL B4DEK9
UniProt Splice Variant
Entrez Gene 7869
UniGene
RefSeq NM_001290060 NM_001290061 NM_001005914 NM_001290062 NM_004636
HUGO HGNC:10724
OMIM 601281
CCDS CCDS74941
HPRD
IMGT
EMBL AK293678
GenPept BAG57120
RNA Seq Atlas 102465526 7869