Homo sapiens Gene: NLK
Summary
InnateDB Gene IDBG-36215.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NLK
Gene Name nemo-like kinase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000087095
Encoded Proteins
nemo-like kinase
nemo-like kinase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 17:28041737-28196381
Strand Forward strand
Band q11.2
Transcripts
ENST00000407008 ENSP00000384625
ENST00000496808 ENSP00000433117
ENST00000584188
ENST00000584878
ENST00000583517
ENST00000582037 ENSP00000464656
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 73 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 73 [view]
Protein-Protein 71 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004707 MAP kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008134 transcription factor binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0031625 ubiquitin protein ligase binding
GO:0042169 SH2 domain binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0016055 Wnt signaling pathway
GO:0018107 peptidyl-threonine phosphorylation
GO:0030178 negative regulation of Wnt signaling pathway
GO:0033136 serine phosphorylation of STAT3 protein
GO:0035556 intracellular signal transduction
GO:0046777 protein autophosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
Wnt pathway
IL6 pathway
REACTOME
Ca2+ pathway pathway
beta-catenin independent WNT signaling pathway
Signaling by Wnt pathway
Signal Transduction pathway
KEGG
MAPK signaling pathway pathway
Wnt signaling pathway pathway
Adherens junction pathway
INOH
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
Wnt signaling pathway pathway
VEGF signaling pathway pathway
PID BIOCARTA
Wnt signaling pathway [Biocarta view]
PID NCI
Presenilin action in Notch and Wnt signaling
C-MYB transcription factor network
Noncanonical Wnt signaling pathway
Cross-References
SwissProt
TrEMBL J3QSE9
UniProt Splice Variant
Entrez Gene 51701
UniGene Hs.208759 Hs.595185 Hs.606788 Hs.618509 Hs.713098 Hs.736201
RefSeq NM_016231
HUGO HGNC:29858
OMIM 609476
CCDS CCDS11224
HPRD 17637
IMGT
EMBL AC061975 AC090287 AC100852
GenPept
RNA Seq Atlas 51701