Homo sapiens Gene: YES1
Summary
InnateDB Gene IDBG-363.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol YES1
Gene Name v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
Synonyms c-yes; HsT441; P61-YES; Yes;
Species Homo sapiens
Ensembl Gene ENSG00000176105
Encoded Proteins
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:721588-812546
Strand Reverse strand
Band p11.32
Transcripts
ENST00000314574 ENSP00000324740
ENST00000584307 ENSP00000462468
ENST00000581960
ENST00000577961 ENSP00000464380
ENST00000577611
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 70 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 70 [view]
Protein-Protein 68 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005154 epidermal growth factor receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019899 enzyme binding
GO:0044325 ion channel binding
Biological Process
GO:0006464 cellular protein modification process
GO:0006468 protein phosphorylation
GO:0007596 blood coagulation
GO:0015758 glucose transport
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0031295 T cell costimulation
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043114 regulation of vascular permeability
GO:0045087 innate immune response
GO:0046777 protein autophosphorylation
GO:0050900 leukocyte migration
Cellular Component
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
Alpha6Beta4Integrin pathway
KitReceptor pathway
Wnt pathway
TSLP pathway
IL11 pathway
REACTOME
Developmental Biology pathway
FCGR activation pathway
PECAM1 interactions pathway
EPHB-mediated forward signaling pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Cytokine Signaling in Immune system pathway
Innate Immune System pathway
Signaling by SCF-KIT pathway
Axon guidance pathway
Signal Transduction pathway
CD28 co-stimulation pathway
Adaptive Immune System pathway
Immune System pathway
EPHA-mediated growth cone collapse pathway
Signaling by Interleukins pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
EPH-ephrin mediated repulsion of cells pathway
EPH-Ephrin signaling pathway
Signaling by ERBB2 pathway
Regulation of KIT signaling pathway
Costimulation by the CD28 family pathway
CTLA4 inhibitory signaling pathway
Cell surface interactions at the vascular wall pathway
Hemostasis pathway
Regulation of signaling by CBL pathway
KEGG
Adherens junction pathway
Tight junction pathway
INOH
PID BIOCARTA
PID NCI
Noncanonical Wnt signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.194148 Hs.714213
RefSeq NM_005433
HUGO
OMIM
CCDS CCDS11824
HPRD 01285
IMGT
EMBL
GenPept
RNA Seq Atlas